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arXiv2024

I-MedSAM: Implicit Medical Image Segmentation with Segment Anything

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent methods have been proposed to adapt the foundational Segment Anything Model (SAM) to medical image segmentation. However, they still focus on discrete representations to generate pixel-wise predictions, which are spatially inflexible and scale poorly to higher resolution. In contrast, implicit methods learn continuous representations for segmentation, which is crucial for medical image segmentation. In this paper, we propose I-MedSAM, which leverages the benefits of both continuous representations and SAM, to obtain better cross-domain ability and accurate boundary delineation. Since medical image segmentation needs to predict detailed segmentation boundaries, we designed a novel adapter to enhance the SAM features with high-frequency information during Parameter-Efficient Fine-Tuning (PEFT). To convert the SAM features and coordinates into continuous segmentation output, we utilize Implicit Neural Representation (INR) to learn an implicit segmentation decoder. We also propose an uncertainty-guided sampling strategy for efficient learning of INR. Extensive evaluations on 2D medical image segmentation tasks have shown that our proposed method with only 1.6M trainable parameters outperforms existing methods including discrete and implicit methods. The code will be available at: https://github.com/ucwxb/I-MedSAM.

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arXiv2025

On Splitting Lightweight Semantic Image Segmentation for Wireless Communications

Semantic communication represents a promising technique towards reducing communication costs, especially when dealing with image segmentation, but it still lacks a balance between computational efficiency and bandwidth requirements while maintaining high image segmentation accuracy, particularly in resource-limited environments and changing channel conditions. On the other hand, the more complex and larger semantic image segmentation models become, the more stressed the devices are when processing data. This paper proposes a novel approach to implementing semantic communication based on splitting the semantic image segmentation process between a resource constrained transmitter and the receiver. This allows saving bandwidth by reducing the transmitted data while maintaining the accuracy of the semantic image segmentation. Additionally, it reduces the computational requirements at the resource constrained transmitter compared to doing all the semantic image segmentation in the transmitter. The proposed approach is evaluated by means of simulation-based experiments in terms of different metrics such as computational resource usage, required bit rate and segmentation accuracy. The results when comparing the proposal with the full semantic image segmentation in the transmitter show that up to 72% of the bit rate was reduced in the transmission process. In addition, the computational load of the transmitter is reduced by more than 19%. This reflects the interest of this technique for its application in communication systems, particularly in the upcoming 6G systems.

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arXiv2025

Diversity-enhanced Collaborative Mamba for Semi-supervised Medical Image Segmentation

Acquiring high-quality annotated data for medical image segmentation is tedious and costly. Semi-supervised segmentation techniques alleviate this burden by leveraging unlabeled data to generate pseudo labels. Recently, advanced state space models, represented by Mamba, have shown efficient handling of long-range dependencies. This drives us to explore their potential in semi-supervised medical image segmentation. In this paper, we propose a novel Diversity-enhanced Collaborative Mamba framework (namely DCMamba) for semi-supervised medical image segmentation, which explores and utilizes the diversity from data, network, and feature perspectives. Firstly, from the data perspective, we develop patch-level weak-strong mixing augmentation with Mamba's scanning modeling characteristics. Moreover, from the network perspective, we introduce a diverse-scan collaboration module, which could benefit from the prediction discrepancies arising from different scanning directions. Furthermore, from the feature perspective, we adopt an uncertainty-weighted contrastive learning mechanism to enhance the diversity of feature representation. Experiments demonstrate that our DCMamba significantly outperforms other semi-supervised medical image segmentation methods, e.g., yielding the latest SSM-based method by 6.69% on the Synapse dataset with 20% labeled data.

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arXiv2023

Post-Train Adaptive U-Net for Image Segmentation

Typical neural network architectures used for image segmentation cannot be changed without further training. This is quite limiting as the network might not only be executed on a powerful server, but also on a mobile or edge device. Adaptive neural networks offer a solution to the problem by allowing certain adaptivity after the training process is complete. In this work for the first time, we apply Post-Train Adaptive (PTA) approach to the task of image segmentation. We introduce U-Net+PTA neural network, which can be trained once, and then adapted to different device performance categories. The two key components of the approach are PTA blocks and PTA-sampling training strategy. The post-train configuration can be done at runtime on any inference device including mobile. Also, the PTA approach has allowed to improve image segmentation Dice score on the CamVid dataset. The final trained model can be switched at runtime between 6 PTA configurations, which differ by inference time and quality. Importantly, all of the configurations have better quality than the original U-Net (No PTA) model.

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arXiv2015

Evolving Fuzzy Image Segmentation with Self-Configuration

Current image segmentation techniques usually require that the user tune several parameters in order to obtain maximum segmentation accuracy, a computationally inefficient approach, especially when a large number of images must be processed sequentially in daily practice. The use of evolving fuzzy systems for designing a method that automatically adjusts parameters to segment medical images according to the quality expectation of expert users has been proposed recently (Evolving fuzzy image segmentation EFIS). However, EFIS suffers from a few limitations when used in practice mainly due to some fixed parameters. For instance, EFIS depends on auto-detection of the object of interest for feature calculation, a task that is highly application-dependent. This shortcoming limits the applicability of EFIS, which was proposed with the ultimate goal of offering a generic but adjustable segmentation scheme. In this paper, a new version of EFIS is proposed to overcome these limitations. The new EFIS, called self-configuring EFIS (SC-EFIS), uses available training data to self-estimate the parameters that are fixed in EFIS. As well, the proposed SC-EFIS relies on a feature selection process that does not require auto-detection of an ROI. The proposed SC-EFIS was evaluated using the same segmentation algorithms and the same dataset as for EFIS. The results show that SC-EFIS can provide the same results as EFIS but with a higher level of automation.

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arXiv2022

Less Is More: A Comparison of Active Learning Strategies for 3D Medical Image Segmentation

Since labeling medical image data is a costly and labor-intensive process, active learning has gained much popularity in the medical image segmentation domain in recent years. A variety of active learning strategies have been proposed in the literature, but their effectiveness is highly dependent on the dataset and training scenario. To facilitate the comparison of existing strategies and provide a baseline for evaluating novel strategies, we evaluate the performance of several well-known active learning strategies on three datasets from the Medical Segmentation Decathlon. Additionally, we consider a strided sampling strategy specifically tailored to 3D image data. We demonstrate that both random and strided sampling act as strong baselines and discuss the advantages and disadvantages of the studied methods. To allow other researchers to compare their work to our results, we provide an open-source framework for benchmarking active learning strategies on a variety of medical segmentation datasets.

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arXiv2016

Image Segmentation Using Hierarchical Merge Tree

This paper investigates one of the most fundamental computer vision problems: image segmentation. We propose a supervised hierarchical approach to object-independent image segmentation. Starting with over-segmenting superpixels, we use a tree structure to represent the hierarchy of region merging, by which we reduce the problem of segmenting image regions to finding a set of label assignment to tree nodes. We formulate the tree structure as a constrained conditional model to associate region merging with likelihoods predicted using an ensemble boundary classifier. Final segmentations can then be inferred by finding globally optimal solutions to the model efficiently. We also present an iterative training and testing algorithm that generates various tree structures and combines them to emphasize accurate boundaries by segmentation accumulation. Experiment results and comparisons with other very recent methods on six public data sets demonstrate that our approach achieves the state-of-the-art region accuracy and is very competitive in image segmentation without semantic priors.

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arXiv2019

From Patch to Image Segmentation using Fully Convolutional Networks -- Application to Retinal Images

Deep learning based models, generally, require a large number of samples for appropriate training, a requirement that is difficult to satisfy in the medical field. This issue can usually be avoided with a proper initialization of the weights. On the task of medical image segmentation in general, two techniques are oftentimes employed to tackle the training of a deep network $f_T$. The first one consists in reusing some weights of a network $f_S$ pre-trained on a large scale database ($e.g.$ ImageNet). This procedure, also known as $transfer$ $learning$, happens to reduce the flexibility when it comes to new network design since $f_T$ is constrained to match some parts of $f_S$. The second commonly used technique consists in working on image patches to benefit from the large number of available patches. This paper brings together these two techniques and propose to train $arbitrarily$ $designed$ $networks$ that segment an image in one forward pass, with a focus on relatively small databases. An experimental work have been carried out on the tasks of retinal blood vessel segmentation and the optic disc one, using four publicly available databases. Furthermore, three types of network are considered, going from a very light weighted network to a densely connected one. The final results show the efficiency of the proposed framework along with state of the art results on all the databases.

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arXiv2025

DyCON: Dynamic Uncertainty-aware Consistency and Contrastive Learning for Semi-supervised Medical Image Segmentation

Semi-supervised learning in medical image segmentation leverages unlabeled data to reduce annotation burdens through consistency learning. However, current methods struggle with class imbalance and high uncertainty from pathology variations, leading to inaccurate segmentation in 3D medical images. To address these challenges, we present DyCON, a Dynamic Uncertainty-aware Consistency and Contrastive Learning framework that enhances the generalization of consistency methods with two complementary losses: Uncertainty-aware Consistency Loss (UnCL) and Focal Entropy-aware Contrastive Loss (FeCL). UnCL enforces global consistency by dynamically weighting the contribution of each voxel to the consistency loss based on its uncertainty, preserving high-uncertainty regions instead of filtering them out. Initially, UnCL prioritizes learning from uncertain voxels with lower penalties, encouraging the model to explore challenging regions. As training progress, the penalty shift towards confident voxels to refine predictions and ensure global consistency. Meanwhile, FeCL enhances local feature discrimination in imbalanced regions by introducing dual focal mechanisms and adaptive confidence adjustments into the contrastive principle. These mechanisms jointly prioritizes hard positives and negatives while focusing on uncertain sample pairs, effectively capturing subtle lesion variations under class imbalance. Extensive evaluations on four diverse medical image segmentation datasets (ISLES'22, BraTS'19, LA, Pancreas) show DyCON's superior performance against SOTA methods.

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arXiv2021

Interior point search for nonparametric image segmentation

Precise object boundary detection for automatic image segmentation is critical for image analysis, including that used in computer-aided diagnosis. However, such detection traditionally uses active contour or snake models requiring accurate initialization and parameter optimization. Identifying optimal parameter values requires time-consuming multiple runs and provides results that vary by user expertise, limiting the use of these models in high-throughput or real-time situations. Thus, we developed a nonparametric snake model using an interior point search method applied in iterations to find and improve the set of snake points forming the edge of a shape. At each iteration, one or more snake points are replaced by others in the edge map. We validated the model using binary and continuous edge images of single and multiple objects, and noisy and real images, comparing the results to those obtained using traditional snake models. The proposed model not only provides better results on all image types tested but is more robust than traditional snake models. Unlike traditional snake models, the proposed model requires no user interaction for initializing snakes and no pre-processing of noisy images. Thus, our method offers robust automatic image segmentation that is simpler to use and less time-consuming than traditional snake models

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arXiv2023

Surf-CDM: Score-Based Surface Cold-Diffusion Model For Medical Image Segmentation

Diffusion models have shown impressive performance for image generation, often times outperforming other generative models. Since their introduction, researchers have extended the powerful noise-to-image denoising pipeline to discriminative tasks, including image segmentation. In this work we propose a conditional score-based generative modeling framework for medical image segmentation which relies on a parametric surface representation for the segmentation masks. The surface re-parameterization allows the direct application of standard diffusion theory, as opposed to when the mask is represented as a binary mask. Moreover, we adapted an extended variant of the diffusion technique known as the "cold-diffusion" where the diffusion model can be constructed with deterministic perturbations instead of Gaussian noise, which facilitates significantly faster convergence in the reverse diffusion. We evaluated our method on the segmentation of the left ventricle from 65 transthoracic echocardiogram videos (2230 echo image frames) and compared its performance to the most popular and widely used image segmentation models. Our proposed model not only outperformed the compared methods in terms of segmentation accuracy, but also showed potential in estimating segmentation uncertainties for further downstream analyses due to its inherent generative nature.

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arXiv2019

More unlabelled data or label more data? A study on semi-supervised laparoscopic image segmentation

Improving a semi-supervised image segmentation task has the option of adding more unlabelled images, labelling the unlabelled images or combining both, as neither image acquisition nor expert labelling can be considered trivial in most clinical applications. With a laparoscopic liver image segmentation application, we investigate the performance impact by altering the quantities of labelled and unlabelled training data, using a semi-supervised segmentation algorithm based on the mean teacher learning paradigm. We first report a significantly higher segmentation accuracy, compared with supervised learning. Interestingly, this comparison reveals that the training strategy adopted in the semi-supervised algorithm is also responsible for this observed improvement, in addition to the added unlabelled data. We then compare different combinations of labelled and unlabelled data set sizes for training semi-supervised segmentation networks, to provide a quantitative example of the practically useful trade-off between the two data planning strategies in this surgical guidance application.

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arXiv2026

GeoSelect: Spatial-Program Execution for Training-Free Referring Remote Sensing Image Segmentation

Referring remote sensing image segmentation segments the object named by a natural-language expression in an aerial image. Existing training-free methods resolve the expression through implicit vision-language activations or region-text similarity, which gives weak control over the spatial, superlative, and ordinal relations that dominate aerial referring, such as the rightmost ship or the second court from the left. We propose GeoSelect, a training-free pipeline that reframes referring as the execution of a typed spatial program. A frozen, text-only language model synthesises the expression into a small domain-specific language, a well-formedness checker accepts the program, and a deterministic executor runs it. The central abstraction is a single scored candidate set type under which every operator composes: continuous geometric fields realise position and proximity, while discrete set and order operators add the extremum, ordinal, top-k, and relational constructions that fields alone cannot express. Execution is explicit, so every intermediate is inspectable, and a reliability ladder degrades any failing program to the field-only special case. GeoSelect achieves 58.86 mIoU on RRSIS-D test and 55.27 mIoU on RISBench test, more than twice the best prior training-free method on RRSIS-D, with no referring supervision and on a single GPU. Under a fixed detector and segmenter, explicit execution improves over implicit selectors under the same backbone; the best-box-IoU and outcome-partition diagnostics motivate complementary tests of proposal recall and program-path behaviour, with the program path the clearer priority on RISBench, and an exposure audit shows comparable accuracy on the audited unseen subset. Code and configurations are available at https://github.com/Avalon-S/GeoSelect.

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arXiv2026

Intra- and Cross-Scale Feature Interaction Network for Referring Remote Sensing Image Segmentation

Referring remote sensing image segmentation (RRSIS) is a challenging multimodal task that requires accurate localization and pixel-level segmentation of targets specified by natural-language expressions. Existing RRSIS datasets remain limited in image resolution, scene diversity, and category coverage, which restricts the generalization ability and practical applicability of current methods. To advance this field, we introduce NWPU-Refer, the largest and most diverse bilingual RRSIS dataset to date. It contains 15,003 high-resolution images (1024--2048 px) collected from more than 30 countries across five continents, together with 49,745 annotated targets covering single-object, multi-object, and no-target scenarios. We further propose the Multi-scale Referring Segmentation Network (MRSNet), a framework tailored to the characteristics of remote sensing imagery. Specifically, MRSNet incorporates an Intra-scale Feature Interaction Module (IFIM) to refine fine-grained features within each encoder stage and a Hierarchical Feature Interaction Module (HFIM) to integrate cross-scale information while preserving spatial structure. Extensive experiments on NWPU-Refer and RRSIS-D demonstrate that MRSNet achieves strong and competitive performance across multiple metrics, especially under strict IoU thresholds and IoU-based evaluation, validating the effectiveness of the proposed dataset and model. The dataset and code are publicly available at https://github.com/CVer-Yang/NWPU-Refer.

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arXiv2026

Early Semantic Grounding in Image Editing Models for Zero-Shot Referring Image Segmentation

Instruction-based image editing (IIE) models have recently demonstrated strong capability in modifying specific image regions according to natural language instructions, which implicitly requires identifying where an edit should be applied. This indicates that such models inherently perform language-conditioned visual semantic grounding. In this work, we investigate whether this implicit grounding can be leveraged for zero-shot referring image segmentation (RIS), a task that requires pixel-level localization of objects described by natural language expressions. Through systematic analysis, we reveal that strong foreground-background separability is already present in the internal representations of these models at the earliest denoising timestep, well before any visible image transformation occurs. Building on this insight, we propose a training-free framework that repurposes pretrained image editing models for RIS by exploiting their intermediate representations. Our approach decomposes localization into two complementary components: attention-based spatial priors that estimate where to focus, and feature-based semantic discrimination that determines what to segment. By leveraging feature-space separability, the framework produces accurate segmentation masks using only a single denoising step, without requiring full image synthesis. Extensive experiments on RefCOCO, RefCOCO+, and RefCOCOg demonstrate that our method achieves superior performance over existing zero-shot baselines. Project page: \url{https://jessie459.github.io/EarlySemanticGrounding/}.

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arXiv2024

Uncertainty Quantification using Variational Inference for Biomedical Image Segmentation

Deep learning motivated by convolutional neural networks has been highly successful in a range of medical imaging problems like image classification, image segmentation, image synthesis etc. However for validation and interpretability, not only do we need the predictions made by the model but also how confident it is while making those predictions. This is important in safety critical applications for the people to accept it. In this work, we used an encoder decoder architecture based on variational inference techniques for segmenting brain tumour images. We evaluate our work on the publicly available BRATS dataset using Dice Similarity Coefficient (DSC) and Intersection Over Union (IOU) as the evaluation metrics. Our model is able to segment brain tumours while taking into account both aleatoric uncertainty and epistemic uncertainty in a principled bayesian manner.

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arXiv2020

A Sim2Real Deep Learning Approach for the Transformation of Images from Multiple Vehicle-Mounted Cameras to a Semantically Segmented Image in Bird's Eye View

Accurate environment perception is essential for automated driving. When using monocular cameras, the distance estimation of elements in the environment poses a major challenge. Distances can be more easily estimated when the camera perspective is transformed to a bird's eye view (BEV). For flat surfaces, Inverse Perspective Mapping (IPM) can accurately transform images to a BEV. Three-dimensional objects such as vehicles and vulnerable road users are distorted by this transformation making it difficult to estimate their position relative to the sensor. This paper describes a methodology to obtain a corrected 360° BEV image given images from multiple vehicle-mounted cameras. The corrected BEV image is segmented into semantic classes and includes a prediction of occluded areas. The neural network approach does not rely on manually labeled data, but is trained on a synthetic dataset in such a way that it generalizes well to real-world data. By using semantically segmented images as input, we reduce the reality gap between simulated and real-world data and are able to show that our method can be successfully applied in the real world. Extensive experiments conducted on the synthetic data demonstrate the superiority of our approach compared to IPM. Source code and datasets are available at https://github.com/ika-rwth-aachen/Cam2BEV

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arXiv2021

Adapting Off-the-Shelf Source Segmenter for Target Medical Image Segmentation

Unsupervised domain adaptation (UDA) aims to transfer knowledge learned from a labeled source domain to an unlabeled and unseen target domain, which is usually trained on data from both domains. Access to the source domain data at the adaptation stage, however, is often limited, due to data storage or privacy issues. To alleviate this, in this work, we target source free UDA for segmentation, and propose to adapt an ``off-the-shelf" segmentation model pre-trained in the source domain to the target domain, with an adaptive batch-wise normalization statistics adaptation framework. Specifically, the domain-specific low-order batch statistics, i.e., mean and variance, are gradually adapted with an exponential momentum decay scheme, while the consistency of domain shareable high-order batch statistics, i.e., scaling and shifting parameters, is explicitly enforced by our optimization objective. The transferability of each channel is adaptively measured first from which to balance the contribution of each channel. Moreover, the proposed source free UDA framework is orthogonal to unsupervised learning methods, e.g., self-entropy minimization, which can thus be simply added on top of our framework. Extensive experiments on the BraTS 2018 database show that our source free UDA framework outperformed existing source-relaxed UDA methods for the cross-subtype UDA segmentation task and yielded comparable results for the cross-modality UDA segmentation task, compared with a supervised UDA methods with the source data.

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