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arXiv2026

Beyond Blur: A Semantic Tri-view Pipeline for Teledermatology Gradability via Skin Micro-relief

Smartphone skin photographs are indispensable to teledermatology, yet assessing the diagnostic suitability of submitted cases (gradability) remains a critical bottleneck in mobile care workflows. Dermatologists routinely review multiple photographic views (regional, angled, and close-up) to identify consistent textural detail rather than relying on a single image. We present the Semantic Tri-view Pipeline, an interpretable architecture for automated teledermatology gradability screening that formalizes epidermal micro-relief as a computable biomarker of image quality. Using an expert-annotated subset of the public SCIN dataset, we train a lightweight DeepLabV3+ model to segment micro-relief fidelity. These spatial masks are then aggregated across up to three case views with a logistic regression classifier, leveraging viewpoint redundancy to support robustness under uncontrolled smartphone acquisition. This approach learns context-aware, clinically intelligible heuristics, such as penalizing high-fidelity texture in regional distance views. Evaluated at a predefined 90% sensitivity operating point, the system's apparent errors largely reflect subjective clinical variance on borderline cases where clinicians rely on non-visual metadata. On SCIN, performance improves from an AUC of 0.81 (80.6% PPV) on variance-heavy majority-consensus cases to 0.96 (97.7% PPV) on optically unambiguous unanimous cases. Overall, this work delivers an interpretable, privacy-by-design, edge-ready system that can provide real-time feedback during case submission to filter ungradable photo sets before review.

eess.IV↗
arXiv2026

Explainable Multimodal Deep Learning Integrating Imaging and Clinical Data for Oral Potentially Malignant Disorder Detection

Oral potentially malignant disorders (OPMDs) are critical precursors to oral cancer, yet clinical detection remains challenging because of substantial phenotypic heterogeneity and overlap with benign conditions. Although image-based deep learning shows promise for automated screening, visual information alone may be insufficient in real-world settings, where diagnostic decisions also rely on patient-specific risk factors. We developed M2-OPMDNet, a multimodal deep learning framework that integrates co-registered white-light and autofluorescence intraoral images with structured clinical information for OPMD detection. A customized questionnaire was designed to capture clinically relevant risk factors and symptoms in a standardized, reproducible format for integration with image-derived features. Multiple image encoders, including conventional convolutional neural networks and foundation model-based architectures, were evaluated using a prospectively collected dataset reflecting real-world screening conditions. Model interpretability was assessed using SHapley Additive exPlanations (SHAP) to quantify feature- and modality-level contributions. M2-OPMDNet achieved an AUC of 0.952, outperforming unimodal approaches and showing improved performance for visually subtle lesions. SHAP analysis demonstrated that structured clinical variables contributed substantially to risk estimation and complemented imaging features. These results demonstrate that explainable multimodal learning combining white-light and autofluorescence imaging with structured clinical data can provide accurate, transparent, and clinically grounded OPMD detection. M2-OPMDNet offers a scalable framework for real-world oral cancer screening and decision support.

eess.IV↗
arXiv2026

FALCON: Fault-Tolerant Magnetic Tunnel Junction-Based In-Memory Stochastic Architecture for Reliability-Critical Edge AI Applications

As modern data-centric applications such as neural inference and sensor-edge analytics expand, they increasingly encounter the von Neumann memory wall, suffering from excessive data movement overhead and stringent energy constraints. In-Memory Computing (IMC) utilizing emerging non-volatile technologies, such as Magnetic Tunnel Junctions (MTJs), promises to mitigate these bottlenecks. However, conventional binary radix-based IMC architectures suffer from excessive vulnerability to process-induced variations, restricted operating margins, and thermal noise. To bridge the gap between energy efficiency and computational reliability, this work proposes FALCON, a fault-tolerant, MTJ-based in-memory arithmetic architecture integrated with Stochastic Computing (SC). By encoding numerical values into uniform bit-streams, SC naturally absorbs localized soft errors and enables the execution of an essential suite of arithmetic operations using highly compact logic primitives directly within the memory arrays. FALCON integrates a deterministic bit mapping mechanism with reconfigurable logic-in-memory (LIM) structures, eliminating the need to transfer data to external processors or area- and power-hungry random number generators. Experimental results using 14 nm FinFET technology validate the correct functionality of FALCON even under aggressive voltage scaling, severe process variation, and noise injection levels up to 30%, making it a robust framework for reliability-critical edge AI applications. We investigate the proper functionality of FALCON on morphological closing as a realistic noise-tolerant image processing case study.

cs.ET↗
arXiv2026

SCoPE-Reg: Efficient Rigid Ultrasound Slice-to-Volume Registration via State-Space Correlation and Closed-Form Pose Estimation

Ultrasound-guided interventions can require localization of an untracked 2D frame within a 3D anatomical reference. Rigid slice-to-volume registration (SVR) estimates this six-degree-of-freedom pose but remains challenging because of limited anatomical context, acoustic artifacts, and view-dependent appearance. Existing methods often use dense cross-attention, whose cost scales with the product of slice and volume token counts, or direct pose regression without explicit correspondence constraints. We introduce SCoPE-Reg, combining state-space slice--volume interaction, dense 3D coordinate prediction, and parameter-free weighted Kabsch estimation. On SVR tasks from CAMUS and $μ$-RegPro, SCoPE-Reg yields mean target registration errors of $0.73$ mm and $2.27$ mm against $1.24$ mm and $2.63$ mm for the state of the art (SOTA), reduces peak error on CAMUS by 56% below SOTA ($12.5\!\to\!5.5$ mm), and registers $100\%$ and $80\%$ of frames within $3$ mm. On CAMUS at $128^2$ it retains the lowest error at increasing pose-perturbation magnitude. It holds $6.49$ M parameters independent of resolution, sustaining $51$ FPS at $512^2$. SCoPE-Reg establishes a SOTA in rigid ultrasound SVR: by coupling correspondence-based accuracy with bounded worst-case error and resolution-independent cost, it becomes viable at native acquisition resolution during intervention, where prior methods trade accuracy, reliability, or frame rate against one another. Supplementary code provided and will be open-sourced upon acceptance.

eess.IV↗
arXiv2025

L2RDaS: Synthesizing 4D Radar Tensors for Model Generalization via Dataset Expansion

4-dimensional (4D) radar is increasingly adopted in autonomous driving for perception tasks, owing to its robustness under adverse weather conditions. To better utilize the spatial information inherent in 4D radar data, recent deep learning methods have transitioned from using sparse point cloud to 4D radar tensors. However, the scarcity of publicly available 4D radar tensor datasets limits model generalization across diverse driving scenarios. Previous methods addressed this by synthesizing radar data, but the outputs did not fully exploit the spatial information characteristic of 4D radar. To overcome these limitations, we propose LiDAR-to-4D radar data synthesis (L2RDaS), a framework that synthesizes spatially informative 4D radar tensors from LiDAR data available in existing autonomous driving datasets. L2RDaS integrates a modified U-Net architecture to effectively capture spatial information and an object information supplement (OBIS) module to enhance reflection fidelity. This framework enables the synthesis of radar tensors across diverse driving scenarios without additional sensor deployment or data collection. L2RDaS improves model generalization by expanding real datasets with synthetic radar tensors, achieving an average increase of 4.25\% in ${{AP}_{BEV}}$ and 2.87\% in ${{AP}_{3D}}$ across three detection models. Additionally, L2RDaS supports ground-truth augmentation (GT-Aug) by embedding annotated objects into LiDAR data and synthesizing them into radar tensors, resulting in further average increases of 3.75\% in ${{AP}_{BEV}}$ and 4.03\% in ${{AP}_{3D}}$. The implementation will be available at https://github.com/kaist-avelab/K-Radar.

cs.CV↗
arXiv2026

Development and Evaluation of Ultrasound Image Learning Pipelines for MASLD Risk Stratification

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 30% of the general population. Ultrasound-based imaging, including B-mode imaging and shear wave elastography (SWE), is widely used for noninvasive fibrosis assessment; however, the role of deep learning-based ultrasound image learning for MASLD risk stratification remains insufficiently characterized. In this study, we developed and evaluated ultrasound image learning pipelines using B-mode and SWE images for fibrosis staging and identification of patients with at-risk metabolic dysfunction-associated steatohepatitis (MASH). A total of 250 ultrasound examinations, one exam per subject, were included. Model performance was evaluated using 3-fold cross-validation with area under the receiver operating characteristic curve (AUROC). End-to-end SWE image learning achieved performance comparable to operator-guided SWE across fibrosis stages. Overall, SWE-based learning consistently outperformed B-mode image learning in fibrosis staging, with AUROC improvements from 0.64 (95%CI: [0.56, 0.72]) to 0.72 (95% CI: [0.65, 0.79]) for F>=2 (significant fibrosis, p=0.11), from 0.67 (95%CI: [0.58, 0.75]) to 0.78 (95% CI:[0.72, 0.85]) for F>=3 (advanced fibrosis, p=0.02), and from 0.69 (95%CI: [0.56, 0.82]) to 0.80 (95%CI: [0.72, 0.89]) for F4 (cirrhosis, p=0.10). These findings highlight the potential of SWE image learning for MASLD risk stratification.

eess.IV↗
arXiv2026

Orientation-Robust Latent Motion Trajectory Learning for Annotation-free Cardiac Phase Detection in Fetal Echocardiography

Fetal echocardiography is essential for detecting congenital heart disease (CHD), facilitating pregnancy management, optimized delivery planning, and timely postnatal interventions. Among standard imaging planes, the four-chamber view (4CV) provides important information for CHD diagnosis, where clinicians carefully inspect the end-diastolic (ED) and end-systolic (ES) phases to evaluate cardiac structure and motion. Automated detection of these cardiac phases is thus a critical component towards fully automated CHD analysis. However, existing approaches typically rely on manual annotation of ED/ES frames, which is labour-intensive and time-consuming. We present ORBIT (Orientation-Robust Beat Inference from Trajectories), a self-supervised framework that identifies cardiac phases without manual annotations under various fetal heart orientation. ORBIT employs registration as self-supervision task and learns a latent motion trajectory of cardiac deformation, whose turning points capture transitions between cardiac relaxation and contraction, enabling accurate and orientation-robust localization of ED and ES frames across diverse fetal positions. Trained exclusively on normal fetal echocardiography videos, ORBIT achieves consistent performance on both normal (mean absolute error 1.9 frames for ED and 1.6 for ES) and CHD cases (mean absolute error 2.4 frames for ED and 2.1 for ES), outperforming existing annotation-free approaches constrained by fixed orientation assumptions. These results highlight the potential of ORBIT to facilitate robust cardiac phase detection directly from 4CV fetal echocardiography.

eess.IV↗
arXiv2026

CARDINAL Predicts Cardiovascular Risk From Non-contrast Cardiac CT

Cardiovascular risk prediction remains limited by incomplete clinical data and imaging biomarkers that reduce computed tomography (CT) to a small number of handcrafted features. We developed CARDINAL (Cardiovascular Assessment via Representation learning from Deep Imaging with Nested Anatomical Latent embeddings), a clinically grounded framework that learns compact representations from routine non-contrast cardiac CT for major adverse cardiovascular event (MACE) prediction. In 17,659 patients, CARDINAL was evaluated for 1-, 3-, 5-, and 10-year MACE prediction against American Heart Association (AHA) pooled cohort equations (PCE), AHA predicting risk of cardiovascular disease events (PREVENT), coronary artery calcium (CAC), segmentation-derived CT biomarkers, and 70-feature structural radiomics. Gains were largest at longer horizons. At 10 years, CARDINAL (joint) achieved an area under the receiver operating characteristic curve (AUROC) of 0.866 $\pm$ 0.020 and an area under the precision-recall curve (AUPRC) of 0.890 $\pm$ 0.015, compared with an AUROC of 0.826 $\pm$ 0.023 and an AUPRC of 0.826 $\pm$ 0.022 for structural radiomics, the strongest baseline. CARDINAL also achieved the highest survival concordance index (C-index), 0.753 $\pm$ 0.015, and high-versus-low risk-tertile hazard ratio, 10.78 $\pm$ 3.16, with favorable reclassification and exploratory calibration. These findings suggest that non-contrast cardiac CT contains prognostic information beyond conventional risk equations, CAC scoring, and engineered imaging biomarkers.

eess.IV↗
arXiv2026

Neural-Network Maxent: a general extension with learned nonlinearity, applied to time-series for Desert Locust distribution modelling

Species Distribution Modelling (SDM) is essential for understanding how environmental conditions shape biodiversity, particularly for destructive pests such as the Desert Locust (Schistocerca gregaria), whose breeding dynamics are tightly coupled to rapidly evolving environmental conditions. Maxent has become the dominant method for presence-only data, but its reliance on a linear combination of hand chosen feature transforms limits its ability to capture the nonlinear, temporal relationships common in ecological monitoring, where covariates such as precipitation, soil moisture, and vegetation indices evolve meaningfully over time. Standard implementations flatten time-series covariates into independent features, discarding sequential structure that carries critical signal. We introduce RNN Maxent, an extension of the Maxent framework that replaces the fixed feature dictionary with a neural network, specifically a Gated Recurrent Unit (GRU), trained end to end via backpropagation. The approach preserves Maxent's presence only statistical foundations, background normalization, and probability calibration, differing only in that the nonlinearity is learned from data rather than fixed in advance. We apply RNN Maxent to map suitable habitat for the Desert Locust using 50 day environmental time series derived from ERA5 Land, MODIS, and Sentinel 3, maintaining a 7 day gap between covariates and presence records to yield forecasting behavior. Compared against standard Maxent, RNN Maxent improves performance across metrics (ROC AUC 0.862 std 0.036 vs. 0.792; F1 0.671 std 0.056 vs. 0.590).

cs.LG↗
arXiv2026

Is Deformable Image Registration Ready for Brain Metastasis Reirradiation Dose Accumulation? A Longitudinal MRI Benchmark of Registration Accuracy

Dose accumulation is increasingly important in adaptive radiation therapy and reirradiation, but its clinical validity depends on the performance of deformable image registration (DIR). Reirradiation of brain metastases (BMs) with stereotactic radiosurgery (SRS) provides a controlled but clinically meaningful DIR test case: intra-subject brain deformation is usually limited after rigid alignment, yet recurrent lesions can undergo substantial local shape and volume changes that rigid registration cannot capture and can affect dose accumulation. We benchmarked a wide range of learning-based and optimization-based DIR methods on 87 manually screened longitudinal contrast-enhanced T1-weighted MRI lesion pairs from an institutional BM SRS retreatment cohort. Learning-based methods pretrained on healthy-brain MRI were evaluated zero-shot and after instance-specific optimization (ISO) or tumor-proximity target-specific optimization (TSO). Registration was assessed using lesion overlap (Dice), surface distance metrics (HD95 and sASD), target-volume recovery, and runtime and memory. Pretrained learning-based methods showed variable zero-shot performance, while ISO/TSO improved all tested learning-based families. However, optimization-based methods remained the best-performing approach while maintaining reasonable runtime. These findings suggest that even state-of-the-art DIR methods do not yet provide sufficiently accurate and consistent registration for unmonitored use in brain metastasis reirradiation dose accumulation. Because accurate registration is a prerequisite for deformable dose accumulation, clinical application will require case-level quality control and direct assessment of how registration uncertainty affects downstream dose metrics.

eess.IV↗
arXiv2026

ViT3Flow: A Test-Time Training Transformer MeanFlow for Postoperative Radiograph Synthesis in Scoliosis

Predicting postoperative spinal morphology from preoperative radiographs could provide valuable support for scoliosis surgical planning, but remains challenging because surgical correction induces large spatial changes while anatomical structures must be faithfully retained. We formulate this problem as postoperative scoliosis radiograph synthesis and construct ScoliSurg, the first paired dataset for this task, comprising 632 preoperative--postoperative whole-spine radiograph pairs with structured morphology information. We further propose ViT$^{3}$Flow, a single-NFE conditional MeanFlow framework for efficient postoperative radiograph synthesis. ViT$^{3}$Flow models surgical correction as finite-interval generative transport and replaces conventional self-attention with test-time-training token mixers that perform sample-specific inner adaptation to the anatomy and deformity pattern of each case. In addition, a Spinal Morphology Extraction Agent extracts distributions of dominant-curve region and direction from the preoperative radiograph. These distributions guide Diagnosis-Routed Interval Cross-Attention (DRICA), which performs interval-dependent vertical, horizontal, joint, and global retrieval from a separate preoperative token stream. This design enables the evolving postoperative representation to incorporate spatially corresponding anatomical evidence throughout the transport process. Extensive experiments on ScoliSurg demonstrate that ViT$^{3}$Flow achieves the best performance among the compared methods in perceptual image quality, anatomical fidelity, and clinically relevant geometric accuracy, while requiring only a single network evaluation. These results highlight the potential of ViT$^{3}$Flow for efficient and anatomically faithful postoperative radiograph synthesis in scoliosis surgical planning.

cs.CV↗
arXiv2026

Scalable Neural Video Representation Compression

Scalable video coding (SVC) encodes a video into a layered bitstream consisting of a base layer and one or multiple enhancement layers, enabling decoding at different bitrate/quality/resolution operating points to accommodate diverse device capabilities and network conditions. Due to its practical flexibility, SVC has been incorporated into major video coding standards and has recently attracted growing interest for both scene-agnostic and scene-adaptive neural video codecs. Among the latter, Implicit neural representation (INR) based codecs achieve compression by overfitting a compact neural network to an individual video, offering fast decoding and competitive coding efficiency compared to scene-agnostic neural codecs. However, research on scalable INR-based compression remains in its infancy: these methods support scalable coding by introducing additional network layers, which couple the bitrate with the decoding complexity and also cannot achieve comparable performance with strong scalable/non-scalable codecs. In this context, this paper proposes S-NVRC, a scalable INR-based video codec that jointly supports fine-grained bitrate and decoding complexity scalability from a single embedded bitstream. It adopts a coarse-to-fine prefix for feature grids and a nested prefix for network layers, which scale bitrate and decoding complexity, respectively. The proposed S-NVRC spans a wide range of bitrate and decoding-complexity using a single encoding (training) and outperforms SHM 12.4 and the multi-layer VTM-20.0, by 43.7% and 5.6% in BD-rate on the UVG dataset, while also providing flexible complexity scalability. Implemented code will be provided.

eess.IV↗
arXiv2026

Evaluating the Safety of Deep Learning-Based Brain MRI Reconstruction

Objective: Deep learning accelerates brain MRI four- to tenfold, but models can erase lesions or synthesize false tissue - failures pixel-averaged metrics like PSNR and SSIM miss. We review whether current evaluation practices detect this blind spot. Methods: Following PRISMA 2020, we searched seven databases without date limits, including 263 studies (1995-2026), appraised them using QUADAS-2 and matched instruments, and synthesized narratively. Categories were derived from titles, abstracts, and controlled vocabulary; reported prevalence figures represent floors. Duplicate screening achieved high agreement (Fleiss kappa = 0.877), as did appraisal (0.788; 0.390 where observable). Extraction is unaudited. Results: Only 18 of 263 studies (6.8%) recorded both a fidelity metric and reader assessment on identical data, leaving the central surrogate unmeasured. Reader studies mostly measured inter-reader agreement, which was weak: fastMRI 2020 concordance reached 0.457 and 0.386 (Kendall W), improving only where SSIM diverged. Erasing a 100 mm3 lacunar infarct shifts global PSNR by 0.03 dB under the stated error model. As the corpus grew fivefold, reader assessments dropped from 32% to 18%, recovering to 21%. Generative models - most associated with hallucination (39%) - were among the least reader-evaluated (11.3%), while self-supervised models reached 47% with zero reader evaluation. Only 5% released code and ran reader studies; none evaluated a model observer; no named dataset covered acute stroke or hemorrhage. Conclusions: On these floors, current evaluation practices cannot certify diagnostic safety. We derive five requirements safety-oriented evaluations must meet.

eess.IV↗
arXiv2026

Semantic-Guided Multimodal Preprocessing for Vision Transformer-Based Clear Cell Renal Cell Carcinoma Grading

Clear cell renal cell carcinoma (CCRCC) grading is essential for treatment planning, yet existing approaches either analyze patch-level images directly or focus solely on nuclei-level classification, without linking to final tumor grading. We propose a semantic-guided multimodal preprocessing method that integrates nuclei classification maps from existing pre-trained models with RGB histopathology images for Vision Transformer (ViT)-based CCRCC grading. Our approach employs classification map channel concatenation and multiplicative modulation, with optimized overlays to leverage nuclei grading information, while preserving RGB textural features. Evaluation of multiple preprocessing strategies demonstrates that semantic-guided enhancement achieves 0.916 balanced accuracy, outperforming RGB-only baseline (0.707) and max-voting aggregation from prior studies (0.427). Sensitivity analysis reveals that this 21 percentage point improvement over baseline persists even under simulated perturbation at rates matching current state-of-the-art nuclei classification model error thresholds, suggesting both effective semantic utilization and practical robustness. These findings show that preprocessing-based multimodal fusion can leverage the diagnostic potential of existing imperfect nuclei classifiers, effectively bridging previously isolated fine-grained nuclear-level analysis with coarse-grained ViT-based patch classification. Per-class recall was consistent across grades (0.93, 0.91, 0.91), indicating that gains are not concentrated in the majority class. Because the sensitivity analysis perturbs ground-truth maps rather than predictions from an actual nuclei model, this result characterizes robustness under simulated error rather than deployment with a real upstream model, which remains for future work.

cs.CV↗
arXiv2025

Intelligent Software System for Low-Cost, Brightfield Segmentation: Algorithmic Implementation for Cytometric Auto-Analysis

Bright-field microscopy, a cost-effective solution for live-cell culture, is often the only resource available, along with standard CPUs, for many low-budget labs. The inherent challenges of bright-field images -- their noisiness, low contrast, and dynamic morphology -- coupled with a lack of GPU resources and complex software interfaces, hinder the desired research output. This article presents a novel microscopy image analysis framework designed for low-budget labs equipped with a standard CPU desktop. The Python-based program enables cytometric analysis of live, unstained cells in culture through an advanced computer vision and machine learning pipeline. Crucially, the framework operates on label-free data, requiring no manually annotated training data or training phase. It is accessible via a user-friendly, cross-platform GUI that requires no programming skills, while also providing a scripting interface for programmatic control and integration by developers. The end-to-end workflow performs semantic and instance segmentation, feature extraction, analysis, evaluation, and automated report generation. Its modular architecture supports easy maintenance and flexible integration while supporting both single-image and batch processing. Validated on several unstained cell types from the public dataset of livecells, the framework demonstrates superior accuracy and reproducibility compared to contemporary tools like Cellpose and StarDist. Its competitive segmentation speed on a CPU-based platform highlights its significant potential for basic research and clinical applications -- particularly in cell transplantation for personalised medicine and muscle regeneration therapies. The access to the application is available for reproducibility

q-bio.QM↗
arXiv2026

Real-World Multi-Modal and Longitudinal Lung Cancer Dataset

Multi-modal learning has demonstrated strong potential in medical applications by integrating heterogeneous data sources such as medical imaging, clinical records, and genomics to improve predictive performance and support clinical decision-making. However, advances in this area are often constrained by two key challenges: the limited availability of well-curated, ready-to-use datasets that accurately reflect real-world conditions, where medical data are frequently collected inconsistently and are often incomplete; and the inherent difficulty of integrating heterogeneous data modalities. In this work, we introduce a newly curated multi-center, multi-modal, and longitudinal dataset designed to support the evaluation of a wide range of learning pipelines under realistic conditions. The dataset comprises a total of 1,365 lung cancer patients and has three imaging modalities (whole-slide images, CT scans, and PET scans), structured clinical data, transcriptomic, and longitudinal follow-up and treatment information. For each imaging modality the dataset contains more than one instance. Moreover, the dataset exhibits substantial and non-uniform missingness across modalities, making it well-suited for studying robust multi-modal fusion strategies. We further provide both uni-modal and multi-modal benchmarks on the task of 12-month overall survival prediction, disease-specific survival, as well as longitudinal benchmark of hazard prediction under severe missing data. Our results show that, despite high levels of missingness, integrating complementary modalities consistently improves predictive performance over uni-modal approaches, highlighting the value of multi-modal fusion in realistic clinical settings. The dataset and benchmark code are available at https://github.com/ritacmendes/MMIST-LUNG.

eess.IV↗
arXiv2026

Learning Zero-Shot Subject-Driven Video Generation Using 1% Compute

Subject-driven video generation (SDV-Gen) aims to produce videos of a specific subject by adapting a pretrained video model, enabling personalized and application-driven content creation. To achieve this goal, per-subject tuning methods require approximately 200 A100 GPU hours to generate a customized video, whereas zero-shot methods avoid per-subject tuning but typically rely on millions of subject-video pairs for the supervision, incurring massive network fine-tuning costs (10K-200K A100 GPU hours). We propose a data- and compute-efficient zero-shot SDV-Gen framework that avoids test-time per-subject tuning and the use of large-scale subject-video pairs. Our key idea decomposes SDV-Gen into (i) identity injection learned from subject-image pairs and (ii) motion-awareness preservation maintained by a small set of arbitrary videos. We optimize the two tasks with stochastic switching, using random reference-frame sampling and image-token dropout to prevent trivial first-frame copying. Our gradient analysis shows that the two objectives rapidly evolve toward nearly orthogonal update subspaces, explaining the stable optimization. Using CogVideoX-5B, we adapt a single model with 200K subject-image pairs and 4,000 arbitrary videos in 288 A100 GPU hours. This yields about 1% of compute compared to prior zero-shot baselines (i.e., 0.4% of VACE and 2.8% of Phantom) while using no subject-video pairs, yet remaining competitive in subject fidelity and motion quality. We show that the same recipe transfers to Wan 2.1-1.3B and Wan 2.2-5B.

cs.CV↗
arXiv2025

High-Throughput Low-Cost Segmentation of Brightfield Microscopy Live Cell Images

Live cell culture is crucial in biomedical studies for analyzing cell properties and dynamics in vitro. This study focuses on segmenting unstained live cells imaged with bright-field microscopy. While many segmentation approaches exist for microscopic images, none consistently address the challenges of bright-field live-cell imaging with high throughput, where temporal phenotype changes, low contrast, noise, and motion-induced blur from cellular movement remain major obstacles. We developed a low-cost CNN-based pipeline incorporating comparative analysis of frozen encoders within a unified U-Net architecture enhanced with attention mechanisms, instance-aware systems, adaptive loss functions, hard instance retraining, dynamic learning rates, progressive mechanisms to mitigate overfitting, and an ensemble technique. The model was validated on a public dataset featuring diverse live cell variants, showing consistent competitiveness with state-of-the-art methods, achieving 93% test accuracy and an average F1-score of 89% (std. 0.07) on low-contrast, noisy, and blurry images. Notably, the model was trained primarily on bright-field images with limited exposure to phase- contrast microscopy (<20%), yet it generalized effectively to the phase-contrast LIVECell dataset, demonstrating modality, robustness and strong performance. This highlights its potential for real- world laboratory deployment across imaging conditions. The model requires minimal compute power and is adaptable using basic deep learning setups such as Google Colab, making it practical for training on other cell variants. Our pipeline outperforms existing methods in robustness and precision for bright-field microscopy segmentation. The code and dataset are available for reproducibility 1.

q-bio.QM↗