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RSRefSeg: Referring Remote Sensing Image Segmentation with Foundation Models

Referring remote sensing image segmentation is crucial for achieving fine-grained visual understanding through free-format textual input, enabling enhanced scene and object extraction in remote sensing applications. Current research primarily utilizes pre-trained language models to encode textual descriptions and align them with visual modalities, thereby facilitating the expression of relevant visual features. However, these approaches often struggle to establish robust alignments between fine-grained semantic concepts, leading to inconsistent representations across textual and visual information. To address these limitations, we introduce a referring remote sensing image segmentation foundational model, RSRefSeg. RSRefSeg leverages CLIP for visual and textual encoding, employing both global and local textual semantics as filters to generate referring-related visual activation features in the latent space. These activated features then serve as input prompts for SAM, which refines the segmentation masks through its robust visual generalization capabilities. Experimental results on the RRSIS-D dataset demonstrate that RSRefSeg outperforms existing methods, underscoring the effectiveness of foundational models in enhancing multimodal task comprehension. The code is available at \url{https://github.com/KyanChen/RSRefSeg}.

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HybridMamba: A Dual-domain Mamba for 3D Medical Image Segmentation

In the domain of 3D biomedical image segmentation, Mamba exhibits the superior performance for it addresses the limitations in modeling long-range dependencies inherent to CNNs and mitigates the abundant computational overhead associated with Transformer-based frameworks when processing high-resolution medical volumes. However, attaching undue importance to global context modeling may inadvertently compromise critical local structural information, thus leading to boundary ambiguity and regional distortion in segmentation outputs. Therefore, we propose the HybridMamba, an architecture employing dual complementary mechanisms: 1) a feature scanning strategy that progressively integrates representations both axial-traversal and local-adaptive pathways to harmonize the relationship between local and global representations, and 2) a gated module combining spatial-frequency analysis for comprehensive contextual modeling. Besides, we collect a multi-center CT dataset related to lung cancer. Experiments on MRI and CT datasets demonstrate that HybridMamba significantly outperforms the state-of-the-art methods in 3D medical image segmentation.

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A new approach for image segmentation based on diffeomorphic registration and gradient fields

Image segmentation is a fundamental task in computer vision aimed at delineating object boundaries within images. Traditional approaches, such as edge detection and variational methods, have been widely explored, while recent advances in deep learning have shown promising results but often require extensive training data. In this work, we propose a novel variational framework for 2D image segmentation that integrates concepts from shape analysis and diffeomorphic transformations. Our method models segmentation as the deformation of a template curve via a diffeomorphic transformation of the image domain, using the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework. The curve evolution is guided by a loss function that compares the deformed curve to the image gradient field, formulated through the varifold representation of geometric shapes. The approach is implemented in Python with GPU acceleration using the PyKeops library. This framework allows for accurate segmentation with a flexible and theoretically grounded methodology that does not rely on large datasets.

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Voxel-wise Adversarial Semi-supervised Learning for Medical Image Segmentation

Semi-supervised learning for medical image segmentation is an important area of research for alleviating the huge cost associated with the construction of reliable large-scale annotations in the medical domain. Recent semi-supervised approaches have demonstrated promising results by employing consistency regularization, pseudo-labeling techniques, and adversarial learning. These methods primarily attempt to learn the distribution of labeled and unlabeled data by enforcing consistency in the predictions or embedding context. However, previous approaches have focused only on local discrepancy minimization or context relations across single classes. In this paper, we introduce a novel adversarial learning-based semi-supervised segmentation method that effectively embeds both local and global features from multiple hidden layers and learns context relations between multiple classes. Our voxel-wise adversarial learning method utilizes a voxel-wise feature discriminator, which considers multilayer voxel-wise features (involving both local and global features) as an input by embedding class-specific voxel-wise feature distribution. Furthermore, we improve our previous representation learning method by overcoming information loss and learning stability problems, which enables rich representations of labeled data. Our method outperforms current best-performing state-of-the-art semi-supervised learning approaches on the image segmentation of the left atrium (single class) and multiorgan datasets (multiclass). Moreover, our visual interpretation of the feature space demonstrates that our proposed method enables a well-distributed and separated feature space from both labeled and unlabeled data, which improves the overall prediction results.

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DiffRIS: Enhancing Referring Remote Sensing Image Segmentation with Pre-trained Text-to-Image Diffusion Models

Referring remote sensing image segmentation (RRSIS) enables the precise delineation of regions within remote sensing imagery through natural language descriptions, serving critical applications in disaster response, urban development, and environmental monitoring. Despite recent advances, current approaches face significant challenges in processing aerial imagery due to complex object characteristics including scale variations, diverse orientations, and semantic ambiguities inherent to the overhead perspective. To address these limitations, we propose DiffRIS, a novel framework that harnesses the semantic understanding capabilities of pre-trained text-to-image diffusion models for enhanced cross-modal alignment in RRSIS tasks. Our framework introduces two key innovations: a context perception adapter (CP-adapter) that dynamically refines linguistic features through global context modeling and object-aware reasoning, and a progressive cross-modal reasoning decoder (PCMRD) that iteratively aligns textual descriptions with visual regions for precise segmentation. The CP-adapter bridges the domain gap between general vision-language understanding and remote sensing applications, while PCMRD enables fine-grained semantic alignment through multi-scale feature interaction. Comprehensive experiments on three benchmark datasets-RRSIS-D, RefSegRS, and RISBench-demonstrate that DiffRIS consistently outperforms existing methods across all standard metrics, establishing a new state-of-the-art for RRSIS tasks. The significant performance improvements validate the effectiveness of leveraging pre-trained diffusion models for remote sensing applications through our proposed adaptive framework.

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SEG-SAM: Semantic-Guided SAM for Unified Medical Image Segmentation

Recently, developing unified medical image segmentation models gains increasing attention, especially with the advent of the Segment Anything Model (SAM). SAM has shown promising binary segmentation performance in natural domains, however, transferring it to the medical domain remains challenging, as medical images often possess substantial inter-category overlaps. To address this, we propose the SEmantic-Guided SAM (SEG-SAM), a unified medical segmentation model that incorporates semantic medical knowledge to enhance medical segmentation performance. First, to avoid the potential conflict between binary and semantic predictions, we introduce a semantic-aware decoder independent of SAM's original decoder, specialized for both semantic segmentation on the prompted object and classification on unprompted objects in images. To further enhance the model's semantic understanding, we solicit key characteristics of medical categories from large language models and incorporate them into SEG-SAM through a text-to-vision semantic module, adaptively transferring the language information into the visual segmentation task. In the end, we introduce the cross-mask spatial alignment strategy to encourage greater overlap between the predicted masks from SEG-SAM's two decoders, thereby benefiting both predictions. Extensive experiments demonstrate that SEG-SAM outperforms state-of-the-art SAM-based methods in unified binary medical segmentation and task-specific methods in semantic medical segmentation, showcasing promising results and potential for broader medical applications.

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Segmentation-by-Detection: A Cascade Network for Volumetric Medical Image Segmentation

We propose an attention mechanism for 3D medical image segmentation. The method, named segmentation-by-detection, is a cascade of a detection module followed by a segmentation module. The detection module enables a region of interest to come to attention and produces a set of object region candidates which are further used as an attention model. Rather than dealing with the entire volume, the segmentation module distills the information from the potential region. This scheme is an efficient solution for volumetric data as it reduces the influence of the surrounding noise which is especially important for medical data with low signal-to-noise ratio. Experimental results on 3D ultrasound data of the femoral head shows superiority of the proposed method when compared with a standard fully convolutional network like the U-Net.

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FDIF: Formula-Driven supervised Learning with Implicit Functions for 3D Medical Image Segmentation

Deep learning-based 3D medical image segmentation methods relies on large-scale labeled datasets, yet acquiring such data is difficult due to privacy constraints and the high cost of expert annotation. Formula-Driven Supervised Learning (FDSL) offers an appealing alternative by generating training data and labels directly from mathematical formulas. However, existing voxel-based approaches are limited in geometric expressiveness and cannot synthesize realistic textures. We introduce Formula-Driven supervised learning with Implicit Functions (FDIF), a framework that enables scalable pre-training without using any real data and medical expert annotations. FDIF introduces an implicit-function representation based on signed distance functions (SDFs), enabling compact modeling of complex geometries while exploiting the surface representation of SDFs to support controllable synthesis of both geometric and intensity textures. Across three medical image segmentation benchmarks (AMOS, ACDC, and KiTS) and three architectures (SwinUNETR, nnUNet ResEnc-L, and nnUNet Primus-M), FDIF consistently improves over a formula-driven method, and achieves performance comparable to self-supervised approaches pre-trained on large-scale real datasets. We further show that FDIF pre-training also benefits 3D classification tasks, highlighting implicit-function-based formula supervision as a promising paradigm for data-free representation learning. Code is available at https://github.com/yamanoko/FDIF.

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Background Matters: A Cross-view Bidirectional Modeling Framework for Semi-supervised Medical Image Segmentation

Semi-supervised medical image segmentation (SSMIS) leverages unlabeled data to reduce reliance on manually annotated images. However, current SOTA approaches predominantly focus on foreground-oriented modeling (i.e., segmenting only the foreground region) and have largely overlooked the potential benefits of explicitly modeling the background region. Our study theoretically and empirically demonstrates that highly certain predictions in background modeling enhance the confidence of corresponding foreground modeling. Building on this insight, we propose the Cross-view Bidirectional Modeling (CVBM) framework, which introduces a novel perspective by incorporating background modeling to improve foreground modeling performance. Within CVBM, background modeling serves as an auxiliary perspective, providing complementary supervisory signals to enhance the confidence of the foreground model. Additionally, CVBM introduces an innovative bidirectional consistency mechanism, which ensures mutual alignment between foreground predictions and background-guided predictions. Extensive experiments demonstrate that our approach achieves SOTA performance on the LA, Pancreas, ACDC, and HRF datasets. Notably, on the Pancreas dataset, CVBM outperforms fully supervised methods (i.e., DSC: 84.57% vs. 83.89%) while utilizing only 20% of the labeled data. Our code is publicly available at https://github.com/caoluyang0830/CVBM.git.

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U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation

Convolutional Neural Networks (CNNs) and Transformers have been the most popular architectures for biomedical image segmentation, but both of them have limited ability to handle long-range dependencies because of inherent locality or computational complexity. To address this challenge, we introduce U-Mamba, a general-purpose network for biomedical image segmentation. Inspired by the State Space Sequence Models (SSMs), a new family of deep sequence models known for their strong capability in handling long sequences, we design a hybrid CNN-SSM block that integrates the local feature extraction power of convolutional layers with the abilities of SSMs for capturing the long-range dependency. Moreover, U-Mamba enjoys a self-configuring mechanism, allowing it to automatically adapt to various datasets without manual intervention. We conduct extensive experiments on four diverse tasks, including the 3D abdominal organ segmentation in CT and MR images, instrument segmentation in endoscopy images, and cell segmentation in microscopy images. The results reveal that U-Mamba outperforms state-of-the-art CNN-based and Transformer-based segmentation networks across all tasks. This opens new avenues for efficient long-range dependency modeling in biomedical image analysis. The code, models, and data are publicly available at https://wanglab.ai/u-mamba.html.

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MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation

The Segment Anything Model (SAM), a foundation model for general image segmentation, has demonstrated impressive zero-shot performance across numerous natural image segmentation tasks. However, SAM's performance significantly declines when applied to medical images, primarily due to the substantial disparity between natural and medical image domains. To effectively adapt SAM to medical images, it is important to incorporate critical third-dimensional information, i.e., volumetric or temporal knowledge, during fine-tuning. Simultaneously, we aim to harness SAM's pre-trained weights within its original 2D backbone to the fullest extent. In this paper, we introduce a modality-agnostic SAM adaptation framework, named as MA-SAM, that is applicable to various volumetric and video medical data. Our method roots in the parameter-efficient fine-tuning strategy to update only a small portion of weight increments while preserving the majority of SAM's pre-trained weights. By injecting a series of 3D adapters into the transformer blocks of the image encoder, our method enables the pre-trained 2D backbone to extract third-dimensional information from input data. The effectiveness of our method has been comprehensively evaluated on four medical image segmentation tasks, by using 10 public datasets across CT, MRI, and surgical video data. Remarkably, without using any prompt, our method consistently outperforms various state-of-the-art 3D approaches, surpassing nnU-Net by 0.9%, 2.6%, and 9.9% in Dice for CT multi-organ segmentation, MRI prostate segmentation, and surgical scene segmentation respectively. Our model also demonstrates strong generalization, and excels in challenging tumor segmentation when prompts are used. Our code is available at: https://github.com/cchen-cc/MA-SAM.

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Zero-shot Referring Image Segmentation with Global-Local Context Features

Referring image segmentation (RIS) aims to find a segmentation mask given a referring expression grounded to a region of the input image. Collecting labelled datasets for this task, however, is notoriously costly and labor-intensive. To overcome this issue, we propose a simple yet effective zero-shot referring image segmentation method by leveraging the pre-trained cross-modal knowledge from CLIP. In order to obtain segmentation masks grounded to the input text, we propose a mask-guided visual encoder that captures global and local contextual information of an input image. By utilizing instance masks obtained from off-the-shelf mask proposal techniques, our method is able to segment fine-detailed Istance-level groundings. We also introduce a global-local text encoder where the global feature captures complex sentence-level semantics of the entire input expression while the local feature focuses on the target noun phrase extracted by a dependency parser. In our experiments, the proposed method outperforms several zero-shot baselines of the task and even the weakly supervised referring expression segmentation method with substantial margins. Our code is available at https://github.com/Seonghoon-Yu/Zero-shot-RIS.

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Multi-Modal Mutual Attention and Iterative Interaction for Referring Image Segmentation

We address the problem of referring image segmentation that aims to generate a mask for the object specified by a natural language expression. Many recent works utilize Transformer to extract features for the target object by aggregating the attended visual regions. However, the generic attention mechanism in Transformer only uses the language input for attention weight calculation, which does not explicitly fuse language features in its output. Thus, its output feature is dominated by vision information, which limits the model to comprehensively understand the multi-modal information, and brings uncertainty for the subsequent mask decoder to extract the output mask. To address this issue, we propose Multi-Modal Mutual Attention ($\mathrm{M^3Att}$) and Multi-Modal Mutual Decoder ($\mathrm{M^3Dec}$) that better fuse information from the two input modalities. Based on {$\mathrm{M^3Dec}$}, we further propose Iterative Multi-modal Interaction ($\mathrm{IMI}$) to allow continuous and in-depth interactions between language and vision features. Furthermore, we introduce Language Feature Reconstruction ($\mathrm{LFR}$) to prevent the language information from being lost or distorted in the extracted feature. Extensive experiments show that our proposed approach significantly improves the baseline and outperforms state-of-the-art referring image segmentation methods on RefCOCO series datasets consistently.

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Medical Image Segmentation Using Squeeze-and-Expansion Transformers

Medical image segmentation is important for computer-aided diagnosis. Good segmentation demands the model to see the big picture and fine details simultaneously, i.e., to learn image features that incorporate large context while keep high spatial resolutions. To approach this goal, the most widely used methods -- U-Net and variants, extract and fuse multi-scale features. However, the fused features still have small "effective receptive fields" with a focus on local image cues, limiting their performance. In this work, we propose Segtran, an alternative segmentation framework based on transformers, which have unlimited "effective receptive fields" even at high feature resolutions. The core of Segtran is a novel Squeeze-and-Expansion transformer: a squeezed attention block regularizes the self attention of transformers, and an expansion block learns diversified representations. Additionally, we propose a new positional encoding scheme for transformers, imposing a continuity inductive bias for images. Experiments were performed on 2D and 3D medical image segmentation tasks: optic disc/cup segmentation in fundus images (REFUGE'20 challenge), polyp segmentation in colonoscopy images, and brain tumor segmentation in MRI scans (BraTS'19 challenge). Compared with representative existing methods, Segtran consistently achieved the highest segmentation accuracy, and exhibited good cross-domain generalization capabilities. The source code of Segtran is released at https://github.com/askerlee/segtran.

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Multi-scale Hierarchical Vision Transformer with Cascaded Attention Decoding for Medical Image Segmentation

Transformers have shown great success in medical image segmentation. However, transformers may exhibit a limited generalization ability due to the underlying single-scale self-attention (SA) mechanism. In this paper, we address this issue by introducing a Multi-scale hiERarchical vIsion Transformer (MERIT) backbone network, which improves the generalizability of the model by computing SA at multiple scales. We also incorporate an attention-based decoder, namely Cascaded Attention Decoding (CASCADE), for further refinement of multi-stage features generated by MERIT. Finally, we introduce an effective multi-stage feature mixing loss aggregation (MUTATION) method for better model training via implicit ensembling. Our experiments on two widely used medical image segmentation benchmarks (i.e., Synapse Multi-organ, ACDC) demonstrate the superior performance of MERIT over state-of-the-art methods. Our MERIT architecture and MUTATION loss aggregation can be used with downstream medical image and semantic segmentation tasks.

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HiFormer: Hierarchical Multi-scale Representations Using Transformers for Medical Image Segmentation

Convolutional neural networks (CNNs) have been the consensus for medical image segmentation tasks. However, they suffer from the limitation in modeling long-range dependencies and spatial correlations due to the nature of convolution operation. Although transformers were first developed to address this issue, they fail to capture low-level features. In contrast, it is demonstrated that both local and global features are crucial for dense prediction, such as segmenting in challenging contexts. In this paper, we propose HiFormer, a novel method that efficiently bridges a CNN and a transformer for medical image segmentation. Specifically, we design two multi-scale feature representations using the seminal Swin Transformer module and a CNN-based encoder. To secure a fine fusion of global and local features obtained from the two aforementioned representations, we propose a Double-Level Fusion (DLF) module in the skip connection of the encoder-decoder structure. Extensive experiments on various medical image segmentation datasets demonstrate the effectiveness of HiFormer over other CNN-based, transformer-based, and hybrid methods in terms of computational complexity, and quantitative and qualitative results. Our code is publicly available at: https://github.com/amirhossein-kz/HiFormer

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Distillation Learning Guided by Image Reconstruction for One-Shot Medical Image Segmentation

Traditional one-shot medical image segmentation (MIS) methods use registration networks to propagate labels from a reference atlas or rely on comprehensive sampling strategies to generate synthetic labeled data for training. However, these methods often struggle with registration errors and low-quality synthetic images, leading to poor performance and generalization. To overcome this, we introduce a novel one-shot MIS framework based on knowledge distillation, which allows the network to directly 'see' real images through a distillation process guided by image reconstruction. It focuses on anatomical structures in a single labeled image and a few unlabeled ones. A registration-based data augmentation network creates realistic, labeled samples, while a feature distillation module helps the student network learn segmentation from these samples, guided by the teacher network. During inference, the streamlined student network accurately segments new images. Evaluations on three public datasets (OASIS for T1 brain MRI, BCV for abdomen CT, and VerSe for vertebrae CT) show superior segmentation performance and generalization across different medical image datasets and modalities compared to leading methods. Our code is available at https://github.com/NoviceFodder/OS-MedSeg.

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Cross-supervised Dual Classifiers for Semi-supervised Medical Image Segmentation

Semi-supervised medical image segmentation offers a promising solution for large-scale medical image analysis by significantly reducing the annotation burden while achieving comparable performance. Employing this method exhibits a high degree of potential for optimizing the segmentation process and increasing its feasibility in clinical settings during translational investigations. Recently, cross-supervised training based on different co-training sub-networks has become a standard paradigm for this task. Still, the critical issues of sub-network disagreement and label-noise suppression require further attention and progress in cross-supervised training. This paper proposes a cross-supervised learning framework based on dual classifiers (DC-Net), including an evidential classifier and a vanilla classifier. The two classifiers exhibit complementary characteristics, enabling them to handle disagreement effectively and generate more robust and accurate pseudo-labels for unlabeled data. We also incorporate the uncertainty estimation from the evidential classifier into cross-supervised training to alleviate the negative effect of the error supervision signal. The extensive experiments on LA and Pancreas-CT dataset illustrate that DC-Net outperforms other state-of-the-art methods for semi-supervised segmentation. The code will be released soon.

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