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arXiv2026

Metrization of Quasi-Uniformities, Powerset Monads, and Qualitative Robustness Analysis

We study the relationship between quasi-uniform spaces, topological spaces, and quantale-valued metric spaces. Our main result is a metrization theorem establishing an equivalence between the category of quasi-uniform spaces and a category of quantale-valued metric spaces. We also obtain a quantale-based metrization theorem for arbitrary topological spaces that refines existing constructions. These results identify quasi-uniformities as the appropriate qualitative counterpart of quantale-valued metrics. Building on this correspondence, we show that the Hausdorff-Smyth monad on quantale-valued metric spaces, which is used in quantitative robustness analysis, arises as a lifting of a corresponding monad on quasi-uniform spaces along the equivalence. This provides a unified categorical framework connecting topology, quasi-uniformity, and quantitative robustness analysis.

math.GN↗

arXiv2026

Machine Learning Classification and Portfolio Construction: Does the Loss Function Matter?

Classification outperforms regression across matched machine learning models in portfolio construction. A stacking ensemble of gradient boosted tree, random forest, and neural network yields a value-weighted annualized Sharpe ratio of 2.08 for classification and 1.39 for regression. This outperformance strengthens with class granularity and persists across subsamples and after transaction costs. Spanning tests show that classification retains economically large alphas after we control for regression, whereas regression alphas shrink substantially once we control for classification. These results indicate that classification extracts more return information than matched regression. Our diagnostics trace classification's advantage to more precise separation of return deciles.

q-fin.GN↗

arXiv2026

Algorithmic Collusion by Large Language Models

We conduct experiments with algorithmic pricing agents based on Large Language Models (LLMs). In oligopoly settings, LLM-based pricing agents quickly and autonomously reach supracompetitive prices and profits. Variation in seemingly innocuous phrases in LLM instructions ("prompts") substantially influence the degree of supracompetitive pricing. We develop novel techniques for behavioral analysis of LLMs and use them to uncover price-war concerns as a contributing factor. Our results extend to auction settings. Our findings uncover unique challenges to any future regulation of LLM-based pricing agents, and AI-based pricing agents more broadly.

econ.GN↗

arXiv2026

VizIt: A multi-view framework for exploring single-cell, spatial, and genetic data online

Multi-omic studies increasingly require data to be examined from complementary biological perspectives, yet interactive exploration remains fragmented across modalities and tools. We present VizIt, an open-source framework for multi-view exploration of single-cell and spatial transcriptomic, epigenomic and genetic data. VizIt connects gene-, cell type-, condition-, spatial-, genomic region- and variant-centered views, enabling seamless navigation across biological perspectives. We demonstrate VizIt through the Parkinson's Cell Atlas, a customizable interactive multi-omic resource.

cs.IR↗

arXiv2026

How Wasteful is Signaling?

Signaling is wasteful. But how wasteful? We study the fraction of surplus dissipated in a separating equilibrium. For isoelastic environments, this waste ratio has a simple formula: $β/(β+σ)$, where $β$ is the benefit elasticity (reward to higher perception) and $σ$ is the elasticity of higher types' relative cost advantage. The ratio is constant across types and is independent of other parameters, including convexity of cost in the signal. We show that the directional effects of $β$ and $σ$ on waste extend to non-isoelastic environments. In an application to signaling tournaments, more competitors or fewer prizes increase waste, with full dissipation in large tournaments.

econ.GN↗

arXiv2026

Individualized Algorithmic Advice as a Strategic Signal on Competitive Markets

As algorithms increasingly mediate competitive decision-making, their influence extends beyond individual outcomes to shaping strategic market dynamics. In our experiment, we examined how algorithmic advice affects human behavior in a classic economic game with a unique, non-collusive, and analytically traceable equilibrium. Participants (N = 129) played a Cournot quantity competition with equilibrium-aligned or strategically biased algorithmic recommendations. While individualized equilibrium advice supported stable convergence, collusively downward-biased advice led to sustained underproduction and supracompetitive profits - hallmarks of tacit collusion. Participants' quantities converged faster and more consistently toward individualized than collective equilibrium advice, potentially due to an objective quality advantage or greater perceived ownership of the former. These findings demonstrate that algorithmic advice can function as a strategic signal, shaping coordination even without explicit communication. The results echo real-world concerns about algorithmic collusion and underscore the need for careful design and oversight of algorithmic decision-support systems in competitive environments.

cs.HC↗

arXiv2026

Scaling an Autoregressive Transformer for Single-Cell Generation

We study a self-supervised generation task for single-cell gene expression vectors: given a set of vectors from a cell type, we aim to generate additional gene expression vectors of that cell type. For this task we characterize both the biological fidelity of the generated gene expression vectors and the scaling behavior of the pretraining loss. The model is a causal transformer paired with a learned quantized VAE tokenizer, trained with a cross-entropy loss. To evaluate the model, we condition it on held-out gene expression vectors of a cell type and generate vectors of gene expression, comparing the resulting distribution over gene expression vectors to the ground truth distribution of that cell type. We study the scaling properties of the proposed architecture by varying the number of trained parameters and the amount of training data. To our knowledge, we find the first jointly-fit two-exponent scaling law and compute-optimal frontier for a single-cell foundation model. Finally, we discuss how this pretrained model could be finetuned for perturbation response prediction.

cs.LG↗

arXiv2026

Subcellularly Resolved Single-Cell Embedding Learning with Transcriptomic data, Protein Structure and Localization Information

Existing cell embedding methods predominantly rely on transcriptomic or proteomic measurements and represent each cell as a holistic entity, thereby overlooking the subcellular localization of individual molecules. Moreover, they rarely incorporate protein structural information, despite its fundamental role in determining molecular interactions and functions. In this work, we propose a multimodal framework for learning subcellularly resolved cell embeddings by jointly leveraging RNA expression profiles, protein sequence representations, and protein structural information. Specifically, we employ a cross-attention architecture to integrate transcriptomic, sequence, and structural modalities and model their interactions within distinct subcellular compartments. The resulting embeddings represent each cell through its fine-grained subcellular organization, capturing both molecular expression patterns and the functional properties of the associated proteins. By learning cell representations at subcellular resolution, our framework preserves spatially organized biological information while integrating complementary signals across multiple molecular levels. To the best of our knowledge, this is the first framework that produces subcellularly resolved cell embeddings by jointly incorporating transcriptomic information, protein sequence representations, and protein structural knowledge within a unified cross-modal learning paradigm.

q-bio.GN↗

arXiv2026

Dutch Books for Language Models

People increasingly use language models to support life decisions. Many such decisions involve a probabilistic forecast: How likely is a major life event, a natural disaster, or an economic outcome? Users of language models may implicitly trust that these forecasts fall out of a coherent world model. In this paper, we evaluate the coherence of language model probabilistic forecasts through a procedure that builds on a theorem due to de Finetti. We elicit forecasts from language models across events generated from stock returns data. We then use linear programs to compute the largest Dutch-book profit - the profit an arbitrageur could guarantee by betting against model-generated probabilities - which we use as a measure of incoherence. Our procedure does not require outcome labels, so we can evaluate coherence even in settings where outcomes are not observed or have not yet resolved. We find substantial evidence of incoherence in language model forecasts. Such incoherence increases when there are richer logical relationships between events, and irrelevant contextual details can increase incoherence by an order of magnitude. We conclude by discussing how alternative training strategies may improve probabilistic coherence.

econ.GN↗

arXiv2026

A Semantic Model of Genetic Evidence: A Step Toward Bridging the Basic-Science-Clinic Gap

Scientific and clinical decision-making depends on evidence from the primary literature, but existing standards for representing that evidence (FHIR Evidence, ECO, SEPIO, and the GA4GH Genomic Knowledge Standards) are oriented toward clinical-trial workflows, evidence codes, or single-variant assertions, and do not capture the fine-grained, domain-specific structure of claims in basic and pre-clinical research. We introduce a semantic model for scientific evidence with three core classes, specialize it for genetics, align it structurally to FHIR Evidence with a SEPIO-anchored credibility decomposition, and attach a compact dimensional vocabulary whose conditional-activation rules are validated by a SHACL schema for the implemented constraints. Using clinical variant interpretation as the driving use case, we evaluate the model through a human-AI annotation pilot over six genetics papers, yielding 28 evidence items and 95 source-anchored assertions, with a workflow that keeps curator-authored reference annotations distinct from AI-drafted annotations. Treating the pilot as a feasibility study rather than a benchmark, we argue that the model is a useful increment toward trustworthy, AI-ready infrastructure for variant interpretation: a reference data model and validation schema for representing genetic evidence.

cs.DB↗

arXiv2026

Competitive Market Behavior of LLMs

Large language models (LLMs) are increasingly deployed as economic agents, yet there is little evidence whether LLM agents are suited for participating in market mechanisms designed for humans, and whether these mechanisms deliver desired outcomes when faced with LLM agents. We address this question by replicating seminal economic experiments, replacing human subjects with LLM agents. We place agents in a double auction environment, which is a widely-used market mechanism. We check whether such a market is able to deliver an efficient allocation of resources, thereby testing a novel dimension of alignment of LLM agents -- their compatibility with a fundamental market mechanism. We find that markets populated by LLM agents exhibit slower or no convergence towards market equilibrium, thus providing less efficient allocations than markets populated by humans. We then analyze agents' individual trading decisions and find substantial heterogeneity both across model families and market roles. We also run a lexical analysis of Chain-of-Thought (CoT) traces generated by the agents. We find that the decision to execute a trade rather than continue incrementally adjusting prices is associated with a shift from strategic considerations toward urgency. We publicly release our testing framework, which can be used for future evaluations.

cs.MA↗

arXiv2026

Tempting the Agent: The Economics of Reputation without Persistent Identity in AI Agent Markets

Reputation is a fundamental mechanism through which markets sustain trust when service quality cannot be perfectly assessed ex ante, constituting a form of intertemporal economic capital by attracting future demand. Its effectiveness as a disciplinary mechanism depends not only on past interactions but also on the persistence of the identity to which reputation is attached. When identities can be abandoned and recreated cheaply, reputational capital may itself become an object of opportunistic exploitation. This paper develops a dynamic economic framework to study when reputation is sufficient to discipline autonomous agents. We model reputation as capital attracting future economic activity. At each point, an agent chooses between operating honestly, investing in quality to preserve future gains, or executing a one-shot deviation to extract its reputation's value and restart from a penalized identity. Our analysis relates the temptation to opportunistic behavior to identity-reset costs, reputation persistence, demand sensitivity, and enforcement design, deriving comparative statics on optimal quality provision. Autonomous AI-agent operating on the blockchain are a relevant application: infrastructures such as ERC-8004, ERC-8183, and x402 combine reputation, identity, and payments in permissionless markets. Nonetheless, our framework applies to any environment where reputation generates future business and identities are replaceable.

q-fin.GN↗

arXiv2026

Evaluating Impacts of Traffic Regulations in Complex Mobility Systems Using Scenario-Based Simulations

Urban traffic regulation policies are increasingly used to address congestion, emissions, and accessibility in cities, yet their impacts are difficult to assess due to the socio-technical complexity of urban mobility systems. Recent advances in data availability and computational power enable new forms of model-driven, simulation-based decision support for transportation policy design. This paper proposes a novel simulation paradigm for the ex-ante evaluation of direct and indirect impacts, spanning traffic conditions, transportation-related effects and economic accessibility. The approach integrates a multi-layer urban mobility model combining a physical layer of mobility flows and emissions with a social layer capturing behavioral responses and adaptation to policy changes. Real-world data are used to instantiate the current as-is scenario, while policy alternatives and behavioral assumptions are encoded as model parameters to generate multiple what-if scenarios. The framework supports systematic comparison across scenarios by analyzing variations in simulated outcomes induced by policy interventions. The proposed approach is illustrated through a case study that aims to assess the impacts of the introduction of broad urban traffic restriction schemes. Results demonstrate the framework's ability to explore alternative regulatory designs and user responses, supporting informed and anticipatory evaluation of urban traffic policies.

cs.CY↗

arXiv2026

PopPert: Population-level Joint-Distribution Modeling for Single-Cell Perturbation Prediction

Predicting transcriptional responses to specific perturbations is critical for understanding cellular regulatory mechanisms and accelerating drug discovery. Single-cell RNA sequencing destroys each measured cell, yielding only unpaired populations of control and perturbed cells. However, existing methods typically model perturbation prediction at the single-cell level and assume cell-to-cell correspondence, which conflicts with the unpaired nature of the observed data. To address this challenge, we propose PopPert, a framework that explicitly parameterizes population-level joint gene expression distributions for collective transcriptional state modeling. Given a control population distribution and a perturbation condition, PopPert predicts perturbation-induced changes in distribution parameters, eliminating the need for cell-level correspondence and reducing sensitivity to single-cell noise. To effectively capture gene co-expression patterns, PopPert leverages a low-rank Gaussian Copula to model cross-gene statistical dependencies and construct the joint gene expression distribution, additionally allowing sampling of synthetic perturbed single-cell profiles. Across multiple single-cell benchmarks spanning both genetic and chemical perturbations, PopPert achieves superior overall performance in differential expression recovery, perturbation effect estimation, and population-level distribution matching. These results establish population-level joint distribution learning as an effective paradigm for predicting transcriptional responses from unpaired single-cell populations. Code for PopPert is publicly available at https://github.com/whd1125/PopPert.

q-bio.GN↗

arXiv2026

Performance Manipulation: Labor Market Implications in AI-assisted Era

Performance manipulation arises when agents exploit easily measurable, routine tasks to inflate observable outcomes without contributing genuine innovation or expert judgment. We formalize this phenomenon in a game-theoretic model in which agents allocate effort along two margins. Creative effort is non-routine cognitive labor whose return is complementary to the agent's private expertise; it is the scarce input that principals seek. Mechanistic effort is the execution of well-defined, rule-based tasks that raise performance independently of expertise, a commoditized input that AI heavily augments. We establish the existence of a symmetric, monotone pure-strategy equilibrium and show that performance-based screening remains viable so long as evaluations retain a sufficient creative component, but collapses into an uninformative pooling equilibrium once AI capability grows large enough to crowd out creative effort. Comparing contest allocations against a single-agent baseline isolates performance manipulation as the competition-induced over-investment in mechanistic effort, which we show is undertaken systematically by low-type agents but not high-type ones. We further prove that more sharply skewed reward structures mitigate this friction by eliciting greater creative effort across the participant pool. Finally, using a novel, language-model-based methodology to measure both effort types from nearly 1,500 Kaggle competition scripts, we provide robust empirical support for the model's predictions.

econ.GN↗

arXiv2026

Forecasting Weather-Driven Price Dynamics Across Sri Lankan Tea Market Catalogues

The Colombo Tea Auction (CTA) plays a vital role in determining global tea prices, yet the relationship between local weather conditions and price behavior across different tea catalogues has not been thoroughly explored. In this study, we develop a novel, structured dataset by extracting information from 105 weekly broker reports spanning late 2023 to 2026, and combined with region-specific weather data. Our analysis focuses on four main tea catalogues of Sri Lankan tea: High Grown, Low Grown, Off-Grade, and Dust. To better understand the factors influencing tea prices, we apply Granger causality analysis alongside tree-based machine learning models: Random Forest, XGBoost, LightGBM, and Gradient Boosting. Our results show that while market dynamics are primary drivers, weather conditions also have significant effects. Notably, Low Grown tea shows strong sensitivity to precipitation and sunshine duration (p<0.05) across 1-3-week lags. Off-Grade and Dust catalogues also exhibit significant responses to temperature variations. Catalogue-specific modelling outperformed unified approaches, with LightGBM emerging as the superior model for three out of four catalogues. Overall, this study highlights the importance of considering both localized weather patterns and catalogue-level differences when forecasting tea prices, offering a more precise and practical framework for the tea industry.

econ.GN↗

arXiv2026

Tastes without distinction: silicon samples and the synthetic construction of tastes

Large-language models have proven to be remarkable if inconsistent parrots of public attitudes and opinions. The extent to which LLMs are able to produce reasonable approximations of cultural taste remains an open empirical question that becomes more urgent by the day, with market research companies already offering provisional 'synthetic' survey panels and the contamination of standard survey data from LLM-generated responses. In this study, we build on past work on silicon sampling by extending considerations of their ecological, relational, and positional fidelity in the doomain of cultural tastes. We use large-language models from OpenAI, Anthropic, and DeepSeek to produce 554,940 silicon surrogates of survey respondents from the Survey of Public Participation in the Arts (SPPA). We find these silicon surrogates' tastes to be highly stylized facsimiles of human tastes. First, silicon samples are super-omnivorous with a systematic postive-bias for liking. These individual-level bias of silicon samples are not well-explained by the WEIRD-bias often discussed in the literature. Second, the complex relationality in real taste structures is completely distorted among silicon samples. Third, very little of the known cultural alignment between tastes and social space are preserved. Silicon samples juvenilize age-taste associations, resurrect anachronistic class-taste associations, and caricaturize gender- and race-taste associations. Key words: AI, taste, consumption, culture, silicon sampling, meta-analysis.

cs.CL↗

arXiv2026

Large-scale spatial variable gene atlas for spatial transcriptomics

Spatial variable genes (SVGs) reveal critical information about tissue architecture, cellular interactions, and disease microenvironments. As spatial transcriptomics (ST) technologies proliferate, accurately identifying SVGs across diverse platforms, tissue types, and disease contexts has become both a major opportunity and a significant computational challenge. Here, we present a comprehensive benchmarking study of 20 state-of-the-art SVG detection methods using human slides from STimage-1K4M, a large-scale resource of ST data comprising 662 slides from more than 18 tissue types. We evaluate each method across a range of biologically and technically meaningful criteria, including recovery of pathologist-annotated domain-specific markers, cross-slide reproducibility, scalability to high-resolution data, and robustness to technical variation. Our results reveal marked differences in performance depending on tissue type, spatial resolution, and study design. Beyond benchmarking, we construct the first cross-tissue atlas of SVGs, enabling comparative analysis of spatial gene programs across cancer and normal tissues. We observe similarities between pairs of tissues that reflect developmental and functional relationships, such as high overlap between thymus and lymph node, and uncover spatial gene programs associated with metastasis, immune infiltration, and tissue-of-origin identity in cancer. Together, our work defines a framework for evaluating and interpreting spatial gene expression and establishes a reference resource for the ST community.

stat.AP↗