Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

Charles Sanson; Odile Diou; Julie Thevenot; Emmanuel Ibarboure; Alain Soum; Annie Brûlet; Sylvain Miraux; Eric Thiaudière; Sisareuth Tan; Alain Brisson; Vincent Dupuis; Olivier Sandre; Sébastien Lecommandoux

arXiv · 1209.5098

Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy

Charles Sanson·Odile Diou·Julie Thevenot·Emmanuel Ibarboure·Alain Soum·Annie Brûlet·Sylvain Miraux·Eric Thiaudière·Sisareuth Tan·Alain Brisson·Vincent Dupuis·Olivier Sandre·Sébastien Lecommandoux

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Abstract

Hydrophobically modified magnetic nanoparticles (MNPs) were encapsulated within the membrane of poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC-b-PGA) block copolymer vesicles using a nanoprecipitation process. This formulation method provides a high loading of MNPs (up to 70 wt %) together with a good control over the sizes of the vesicles (100 - 400 nm). The deformation of the vesicle membrane under an applied magnetic field was evidenced by anisotropic SANS. These hybrid objects display contrast enhancement properties in Magnetic Resonance Imaging, a diagnostic method routinely used for three-dimensional and non-invasive scans of the human body. They can also be guided in a magnetic field gradient. The feasibility of drug release triggered by magnetic induction was evidenced using the anticancer drug doxorubicin (DOX), which is co-encapsulated in the membrane. Magnetic polymersomes are thus proposed as multimodal drug nanocarriers for bio-imaging and magneto-chemotherapy.

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Charles Sanson, Odile Diou, Julie Thevenot, Emmanuel Ibarboure, Alain Soum, Annie Brûlet, Sylvain Miraux, Eric Thiaudière, Sisareuth Tan, Alain Brisson, Vincent Dupuis, Olivier Sandre, Sébastien Lecommandoux. 2012-09-23. Doxorubicin Loaded Magnetic Polymersomes: Theranostic Nanocarriers for MR Imaging and Magneto-Chemotherapy. https://arxiv.org/abs/1209.5098

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