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arXiv · 1209.5475

Effects of surface functional groups on the formation of nanoparticle-protein corona

Ramakrishna Podila·Ran Chen·Pu Chun Ke·Apparao M. Rao
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Abstract

Herein, we examined the dependence of protein adsorption on the nanoparticle surface in the presence of functional groups. Our UV-visible spectrophotometry, transmission electron microscopy, infrared spectroscopy and dynamic light scattering measurements evidently suggested that the functional groups play an important role in the formation of nanoparticle-protein corona. We found that uncoated and surfactant-free silver nanoparticles derived from a laser ablation process promoted a maximum protein (bovine serum albumin) coating due to increased changes in entropy. On the other hand, BSA displayed a lower affinity for electrostatically stabilized nanoparticles due to the constrained entropy changes.

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Ramakrishna Podila, Ran Chen, Pu Chun Ke, Apparao M. Rao. 2012-09-25. Effects of surface functional groups on the formation of nanoparticle-protein corona. https://doi.org/10.1063/1.4772509

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