Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2311.11862

Establishing Central Sensitization Inventory Cut-off Values in patients with Chronic Low Back Pain by Unsupervised Machine Learning

Xiaoping Zheng·Claudine JC Lamoth·Hans Timmerman·Ebert Otten·Michiel F Reneman
View original source ↗Read source document ↗Export metadata ↓

Abstract

Human Assumed Central Sensitization is involved in the development and maintenance of chronic low back pain (CLBP). The Central Sensitization Inventory (CSI) was developed to evaluate the presence of HACS, with a cut-off value of 40/100 based on patients with chronic pain. However, various factors including pain conditions (e.g., CLBP), and gender may influence this cut-off value. For chronic pain condition such as CLBP, unsupervised clustering approaches can take these factors into consideration and automatically learn the HACS-related patterns. Therefore, this study aimed to determine the cut-off values for a Dutch-speaking population with CLBP, considering the total group and stratified by gender based on unsupervised machine learning. In this study, questionnaire data covering pain, physical, and psychological aspects were collected from patients with CLBP and aged-matched pain-free adults (referred to as healthy controls, HC). Four clustering approaches were applied to identify HACS-related clusters based on the questionnaire data and gender. The clustering performance was assessed using internal and external indicators. Subsequently, receiver operating characteristic analysis was conducted on the best clustering results to determine the optimal cut-off values. The study included 151 subjects, consisting of 63 HCs and 88 patients with CLBP. Hierarchical clustering yielded the best results, identifying three clusters: healthy group, CLBP with low HACS level, and CLBP with high HACS level groups. Based on the low HACS levels group (including HC and CLBP with low HACS level) and high HACS level group, the cut-off value for the overall groups were 35, 34 for females, and 35 for. The findings suggest that the optimal cut-off values for CLBP is 35. The gender-related cut-off values should be interpreted with caution due to the unbalanced gender distribution in the sample.

Explore related subjects

cs.LGcs.AIq-bio.NC

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Xiaoping Zheng, Claudine JC Lamoth, Hans Timmerman, Ebert Otten, Michiel F Reneman. 2023-11-20. Establishing Central Sensitization Inventory Cut-off Values in patients with Chronic Low Back Pain by Unsupervised Machine Learning. https://doi.org/10.1016/j.compbiomed.2024.108739

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Analysis of Regularized Learning in Banach Spaces for Linear-functional Data

This article delves into the study of the theory of regularized learning in Banach spaces for linear-functional data. It encompasses discussions on representer theorems, pseudo-approximation theorems, and convergence theorems. Regularized learning is designed to minimize regularized empirical risks over a Banach space. The empirical risks are calculated by utilizing training data and multi-loss functions. The input training data are composed of linear functionals in a predual space of the Banach space to capture discrete local information from multimodal data and multiscale models. Through the regularized learning, approximations of the exact solution to an unidentified or uncertain original problem are globally achieved. In the convergence theorems, the convergence of the approximate solutions to the exact solution is established through the utilization of the weak* topology of the Banach space. The theorems of regularized learning are utilized in the interpretation of classical machine learning, such as support vector machines and artificial neural networks.

cs.LG↗
arXiv2026

On Minimal Depth in Neural Networks

Understanding the relationship between the depth of a neural network and its representational capacity is a central problem in deep learning theory. In this work, we develop a geometric framework to analyze the expressivity of ReLU networks with the notion of depth complexity for convex polytopes. The depth of a polytope recursively quantifies the number of alternating convex hull and Minkowski sum operations required to construct it. This geometric perspective serves as a rigorous tool for deriving depth lower bounds and understanding the structural limits of deep neural architectures. We establish lower and upper bounds on the depth of polytopes, as well as tight bounds for classical families. These results yield two main consequences. First, we provide a purely geometric proof of the expressivity bound by Arora et al. (2018), confirming that $\lceil \log_2(n+1)\rceil$ hidden layers suffice to represent any continuous piecewise linear (CPWL) function. Second, we prove that, unlike general ReLU networks, convex polytopes do not admit a universal depth bound. Specifically, the depth of cyclic polytopes in dimensions $n \geq 4$ grows unboundedly with the number of vertices. This result implies that Input Convex Neural Networks (ICNNs) cannot represent all convex CPWL functions with a fixed depth, revealing a sharp separation in expressivity between ICNNs and standard ReLU networks.

cs.LG↗
arXiv2026

DeepSPoC: A Deep Learning Based Sequential Propagation of Chaos

Classical particle methods based on propagation of chaos (PoC) have been developed for solving mean-field stochastic differential equations and their associated nonlinear Fokker--Planck equations. However, direct PoC implementations are difficult to apply to high-dimensional problems because they require simulating and storing large numbers of interacting particles, often with high particle-particle interaction costs. Motivated by these limitations, we build on the recently proposed sequential propagation of chaos (SPoC) framework, which replaces the fully interacting particle system in PoC with a sequential interaction mechanism. Based on this structure, we present DeepSPoC, a neural particle method that embeds a neural density representation into the sequential particle dynamics. DeepSPoC simulates particles batch by batch, while the neural network represents the evolving empirical law and is substituted into the coefficients of the mean-field SDE, thereby replacing direct particle-particle interactions with particle-network interactions. In DeepSPoC, a recently developed normalizing flow model called KRnet is used to approximate the empirical measure of particles. Compared with direct particle implementations, DeepSPoC substantially reduces memory consumption and evaluates interaction terms more efficiently, thereby improving scalability for high-dimensional problems. We apply DeepSPoC to a wide range of mean-field equations and verify its effectiveness and computational advantages.

cs.LG↗