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arXiv · 2407.14030

HeCiX: Integrating Knowledge Graphs and Large Language Models for Biomedical Research

Prerana Sanjay Kulkarni·Muskaan Jain·Disha Sheshanarayana·Srinivasan Parthiban
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Abstract

Despite advancements in drug development strategies, 90% of clinical trials fail. This suggests overlooked aspects in target validation and drug optimization. In order to address this, we introduce HeCiX-KG, Hetionet-Clinicaltrials neXus Knowledge Graph, a novel fusion of data from ClinicalTrials.gov and Hetionet in a single knowledge graph. HeCiX-KG combines data on previously conducted clinical trials from ClinicalTrials.gov, and domain expertise on diseases and genes from Hetionet. This offers a thorough resource for clinical researchers. Further, we introduce HeCiX, a system that uses LangChain to integrate HeCiX-KG with GPT-4, and increase its usability. HeCiX shows high performance during evaluation against a range of clinically relevant issues, proving this model to be promising for enhancing the effectiveness of clinical research. Thus, this approach provides a more holistic view of clinical trials and existing biological data.

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Prerana Sanjay Kulkarni, Muskaan Jain, Disha Sheshanarayana, Srinivasan Parthiban. 2024-07-19. HeCiX: Integrating Knowledge Graphs and Large Language Models for Biomedical Research. https://arxiv.org/abs/2407.14030

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