Advancing AI-Powered Medical Image Synthesis: Insights from MedVQA-GI Challenge Using CLIP, Fine-Tuned Stable Diffusion, and Dream-Booth + LoRA

Ojonugwa Oluwafemi Ejiga Peter; Md Mahmudur Rahman; Fahmi Khalifa

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arXiv · 2502.20667

Advancing AI-Powered Medical Image Synthesis: Insights from MedVQA-GI Challenge Using CLIP, Fine-Tuned Stable Diffusion, and Dream-Booth + LoRA

Ojonugwa Oluwafemi Ejiga Peter·Md Mahmudur Rahman·Fahmi Khalifa

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Abstract

The MEDVQA-GI challenge addresses the integration of AI-driven text-to-image generative models in medical diagnostics, aiming to enhance diagnostic capabilities through synthetic image generation. Existing methods primarily focus on static image analysis and lack the dynamic generation of medical imagery from textual descriptions. This study intends to partially close this gap by introducing a novel approach based on fine-tuned generative models to generate dynamic, scalable, and precise images from textual descriptions. Particularly, our system integrates fine-tuned Stable Diffusion and DreamBooth models, as well as Low-Rank Adaptation (LORA), to generate high-fidelity medical images. The problem is around two sub-tasks namely: image synthesis (IS) and optimal prompt production (OPG). The former creates medical images via verbal prompts, whereas the latter provides prompts that produce high-quality images in specified categories. The study emphasizes the limitations of traditional medical image generation methods, such as hand sketching, constrained datasets, static procedures, and generic models. Our evaluation measures showed that Stable Diffusion surpasses CLIP and DreamBooth + LORA in terms of producing high-quality, diversified images. Specifically, Stable Diffusion had the lowest Fréchet Inception Distance (FID) scores (0.099 for single center, 0.064 for multi-center, and 0.067 for combined), indicating higher image quality. Furthermore, it had the highest average Inception Score (2.327 across all datasets), indicating exceptional diversity and quality. This advances the field of AI-powered medical diagnosis. Future research will concentrate on model refining, dataset augmentation, and ethical considerations for efficiently implementing these advances into clinical practice

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Ojonugwa Oluwafemi Ejiga Peter, Md Mahmudur Rahman, Fahmi Khalifa. 2025-08-10. Advancing AI-Powered Medical Image Synthesis: Insights from MedVQA-GI Challenge Using CLIP, Fine-Tuned Stable Diffusion, and Dream-Booth + LoRA. https://arxiv.org/abs/2502.20667

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