Synthesis and characterization of gold-coated nanodiamonds through green chemistry as potential radiosensitizers for proton therapy

Edgar Mendes; Ana Belchior; Federico Picollo; Marta M. Alves; Rodica Mihaela Dinica; Maria Joao Moura; Teresa Pinheiro; Maria Paula Cabral Campello

arXiv · 2504.11061

Synthesis and characterization of gold-coated nanodiamonds through green chemistry as potential radiosensitizers for proton therapy

Edgar Mendes·Ana Belchior·Federico Picollo·Marta M. Alves·Rodica Mihaela Dinica·Maria Joao Moura·Teresa Pinheiro·Maria Paula Cabral Campello

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Abstract

In this work the synthesis and characterization of novel gold-nanodiamond nanoparticles was performed. The synthesis was based on the reduction of gold onto the different types of nanodiamond (annealed or annealed and oxidized, 50 or 230 nm) using root extracts of Nympheaea alba as a reducing agent. These gold-coated nanodiamonds were characterized by UV-Vis, PXRD, DLS, zeta-potential, PIXE, Raman, SEM, and TEM, assessing particle size, stability, and gold coating effectiveness. Cellular studies in the A549 and Panc1 cancer cell lines assessed uptake, cytotoxicity, and colony formation to evaluate NDAu's biological activity. NDAu demonstrated strong cellular uptake and cytotoxic effects in A549 and Panc1 cell lines, reducing cell survival in clonogenic assay. Futher research in the capabilites of these nanoparticles for proton therapy will be performed.

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Edgar Mendes, Ana Belchior, Federico Picollo, Marta M. Alves, Rodica Mihaela Dinica, Maria Joao Moura, Teresa Pinheiro, Maria Paula Cabral Campello. 2025-04-15. Synthesis and characterization of gold-coated nanodiamonds through green chemistry as potential radiosensitizers for proton therapy. https://arxiv.org/abs/2504.11061

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