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arXiv · 2505.20358

Is GGAG:Ce@SiO$_2$-RB composite a prospective material for X-ray induced photodynamic therapy?

Iveta Terezie Hošnová·Kristýna Havlinová·Jan Bárta·Karolína Mocová·Xenie Lytvynenko·Lenka Prouzová Procházková·Vojtěch Kazda·František Hájek·Viliam Múčka·Václav Čuba
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Abstract

Nanocomposite material ($\mathrm{GGAG:Ce^{3+}@SiO_2-RB}$) for potential use in X-ray induced photodynamic therapy (X-PDT) was developed, thoroughly characterized, and evaluated. It consists of a scintillating $\mathrm{Gd_3(Ga_{1-x}Al_x)_5O_{12}:Ce^{3+}}$ core encapsulated in silica layer and functionalized with the photosensitizer Rose Bengal (RB). Radioluminescence measurements confirmed the energy transfer from the scintillating core to Rose Bengal. Dark toxicity and radiosensitisation effects were evaluated using Saccharomyces cerevisiae as a model organism. The nanocomposite showed minimal dark toxicity at concentrations of up to 10 mg/mL. However, X-ray irradiation experiments did not demonstrate significant singlet oxygen production compared to the controls. Although the nanocomposite design shows potential, further optimization is needed to achieve an effective X-PDT performance.

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Iveta Terezie Hošnová, Kristýna Havlinová, Jan Bárta, Karolína Mocová, Xenie Lytvynenko, Lenka Prouzová Procházková, Vojtěch Kazda, František Hájek, Viliam Múčka, Václav Čuba. 2025-05-29. Is GGAG:Ce@SiO$_2$-RB composite a prospective material for X-ray induced photodynamic therapy?. https://doi.org/10.1016/j.radphyschem.2025.112942

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