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arXiv · 2506.02976

Deep Learning for Retinal Degeneration Assessment: A Comprehensive Analysis of the MARIO Challenge

Rachid Zeghlache·Ikram Brahim·Pierre-Henri Conze·Mathieu Lamard·Mohammed El Amine Lazouni·Zineb Aziza Elaouaber·Leila Ryma Lazouni·Christopher Nielsen·Ahmad O. Ahsan·Matthias Wilms·Nils D. Forkert·Lovre Antonio Budimir·Ivana Matovinović·Donik Vršnak·Sven Lončarić·Philippe Zhang·Weili Jiang·Yihao Li·Yiding Hao·Markus Frohmann·Patrick Binder·Marcel Huber·Taha Emre·Teresa Finisterra Araújo·Marzieh Oghbaie·Hrvoje Bogunović·Amerens A. Bekkers·Nina M. van Liebergen·Hugo J. Kuijf·Abdul Qayyum·Moona Mazher·Steven A. Niederer·Alberto J. Beltrán-Carrero·Juan J. Gómez-Valverde·Javier Torresano-Rodríquez·Álvaro Caballero-Sastre·María J. Ledesma Carbayo·Yosuke Yamagishi·Yi Ding·Robin Peretzke·Alexandra Ertl·Maximilian Fischer·Jessica Kächele·Sofiane Zehar·Karim Boukli Hacene·Thomas Monfort·Béatrice Cochener·Mostafa El Habib Daho·Anas-Alexis Benyoussef·Gwenolé Quellec
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Abstract

The MARIO challenge, held at MICCAI 2024, focused on advancing the automated detection and monitoring of age-related macular degeneration (AMD) through the analysis of optical coherence tomography (OCT) images. Designed to evaluate algorithmic performance in detecting neovascular activity changes within AMD, the challenge incorporated unique multi-modal datasets. The primary dataset, sourced from Brest, France, was used by participating teams to train and test their models. The final ranking was determined based on performance on this dataset. An auxiliary dataset from Algeria was used post-challenge to evaluate population and device shifts from submitted solutions. Two tasks were involved in the MARIO challenge. The first one was the classification of evolution between two consecutive 2D OCT B-scans. The second one was the prediction of future AMD evolution over three months for patients undergoing anti-vascular endothelial growth factor (VEGF) therapy. Thirty-five teams participated, with the top 12 finalists presenting their methods. This paper outlines the challenge's structure, tasks, data characteristics, and winning methodologies, setting a benchmark for AMD monitoring using OCT, infrared imaging, and clinical data (such as the number of visits, age, gender, etc.). The results of this challenge indicate that artificial intelligence (AI) performs as well as a physician in measuring AMD progression (Task 1) but is not yet able of predicting future evolution (Task 2).

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Rachid Zeghlache, Ikram Brahim, Pierre-Henri Conze, Mathieu Lamard, Mohammed El Amine Lazouni, Zineb Aziza Elaouaber, Leila Ryma Lazouni, Christopher Nielsen, Ahmad O. Ahsan, Matthias Wilms, Nils D. Forkert, Lovre Antonio Budimir, Ivana Matovinović, Donik Vršnak, Sven Lončarić, Philippe Zhang, Weili Jiang, Yihao Li, Yiding Hao, Markus Frohmann, Patrick Binder, Marcel Huber, Taha Emre, Teresa Finisterra Araújo, Marzieh Oghbaie, Hrvoje Bogunović, Amerens A. Bekkers, Nina M. van Liebergen, Hugo J. Kuijf, Abdul Qayyum, Moona Mazher, Steven A. Niederer, Alberto J. Beltrán-Carrero, Juan J. Gómez-Valverde, Javier Torresano-Rodríquez, Álvaro Caballero-Sastre, María J. Ledesma Carbayo, Yosuke Yamagishi, Yi Ding, Robin Peretzke, Alexandra Ertl, Maximilian Fischer, Jessica Kächele, Sofiane Zehar, Karim Boukli Hacene, Thomas Monfort, Béatrice Cochener, Mostafa El Habib Daho, Anas-Alexis Benyoussef, Gwenolé Quellec. 2026-08-03. Deep Learning for Retinal Degeneration Assessment: A Comprehensive Analysis of the MARIO Challenge. https://arxiv.org/abs/2506.02976

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