Search arXivSearch

arXiv · 2506.22754

Doubly robust estimation of causal effects for random object outcomes with continuous treatments

Abstract

Causal inference is central to statistics and scientific discovery, enabling researchers to identify cause-and-effect relationships beyond associations. While traditionally studied within Euclidean spaces, contemporary applications increasingly involve complex, non-Euclidean data structures that reside in abstract metric spaces, known as random objects, such as images, shapes, networks, and distributions. This paper introduces a novel framework for causal inference with continuous treatments applied to non-Euclidean data. To address the challenges posed by the lack of linear structures, we leverage Hilbert space embeddings of the metric spaces to facilitate Fréchet mean estimation and causal effect mapping. Motivated by a study on the impact of exposure to fine particulate matter on age-at-death distributions across U.S. counties, we propose a nonparametric, doubly-debiased causal inference approach for outcomes as random objects with continuous treatments. Our framework can accommodate moderately high-dimensional vector-valued confounders and derive efficient influence functions for estimation to ensure both robustness and interpretability. We establish rigorous asymptotic properties of the cross-fitted estimators and employ conformal inference techniques for counterfactual outcome prediction. Validated through numerical experiments and applied to real-world environmental data, our framework extends causal inference methodologies to complex data structures, broadening its applicability across scientific disciplines.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Satarupa Bhattacharjee, Bing Li, Xiao Wu, Lingzhou Xue. 2025-06-28. Doubly robust estimation of causal effects for random object outcomes with continuous treatments. https://arxiv.org/abs/2506.22754

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

Generalised Covariances and Correlations

The covariance of two random variables measures the average joint deviations from their respective means. We generalise this well-known measure by replacing the means with other statistical functionals such as quantiles, expectiles, or thresholds. Deviations from these functionals are defined via generalised errors, typically induced through identification or moment functions. As a normalised measure of dependence, a generalised correlation is constructed. Replacing the common Cauchy--Schwarz normalisation by a novel Fréchet--Hoeffding normalisation, we obtain attainability of the entire interval $[-1, 1]$ for any given marginal distributions. We uncover favourable properties of these new dependence measures and establish consistent estimators. The families of quantile and threshold correlations make it possible to measure local dependence and give rise to function-valued distributional correlations, exhibiting the entire dependence structure. Quantile correlations also lead to tail correlations, new measures of tail dependence, closely related to and refining classical coefficients of tail dependence. Finally, we construct summary covariances (correlations), a class of regional or global dependence measures, which arise as (normalised) weighted averages of distributional covariances. We retrieve covariance, Pearson and Spearman correlation as special cases. The usefulness of our new dependence measures is illustrated on demographic data from the Panel Study of Income Dynamics.

stat.ME

Compressive Bayesian non-negative matrix factorization for mutational signatures analysis

Non-negative matrix factorization (NMF) is a popular tool for dimensionality reduction, especially for count matrices. However, inferring an appropriate number of factors is challenging. Existing approaches based on information criteria or nonparametric sparsity-inducing priors tend to be computationally burdensome or highly sensitive to prior choices. Moreover, theoretical properties of the posterior distribution of Poisson NMF parameters endowed with shrinkage priors remain under-explored. This paper introduces a novel Bayesian NMF method that automatically infers the number of factors while also incorporating information on the latent factors from previous studies. This is achieved using compressive hyperpriors, which are hierarchical priors that make the sample-specific weights of unneeded factors concentrate near zero in the posterior. We provide novel distribution theory for posterior inference to elucidate this shrinkage mechanism, both in finite samples and asymptotically. We apply our method to mutational signatures analysis in cancer genomics, in simulations and on real data from breast cancer. Compared to state-of-the-art alternatives, our method is more robust to mild overdispersion and improves detection and estimation of signatures aligned with prior information.

stat.ME

On Relative Cumulative Residual Information Measure and Its Applications

We develop a relative cumulative residual information measure (RCRI) that aims to quantify the divergence between two survival functions. The dynamic relative cumulative residual information (DRCRI) measure is also introduced. We establish some characterization results under the assumption of the proportional hazards model. Additionally, we obtained the non-parametric estimators of RCRI and DRCRI measures based on the kernel density type estimator for the survival function. The effectiveness of the estimators are assessed through an extensive Monte Carlo simulation study. We consider data from the third Gaia data release (Gaia DR3) to demonstrate the use of the proposed measure. For this study, we have collected epoch photometry data for the objects Gaia DR3 4111834567779557376 and Gaia DR3 5090605830056251776. RCRI-based image analysis is conducted using Chest X-ray data from the publicly available dataset.

stat.ME