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arXiv · 2507.14680

WSI-Agents: A Collaborative Multi-Agent System for Multi-Modal Whole Slide Image Analysis

Xinheng Lyu·Yuci Liang·Wenting Chen·Meidan Ding·Jiaqi Yang·Guolin Huang·Daokun Zhang·Xiangjian He·Linlin Shen
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Abstract

Whole slide images (WSIs) are vital in digital pathology, enabling gigapixel tissue analysis across various pathological tasks. While recent advancements in multi-modal large language models (MLLMs) allow multi-task WSI analysis through natural language, they often underperform compared to task-specific models. Collaborative multi-agent systems have emerged as a promising solution to balance versatility and accuracy in healthcare, yet their potential remains underexplored in pathology-specific domains. To address these issues, we propose WSI-Agents, a novel collaborative multi-agent system for multi-modal WSI analysis. WSI-Agents integrates specialized functional agents with robust task allocation and verification mechanisms to enhance both task-specific accuracy and multi-task versatility through three components: (1) a task allocation module assigning tasks to expert agents using a model zoo of patch and WSI level MLLMs, (2) a verification mechanism ensuring accuracy through internal consistency checks and external validation using pathology knowledge bases and domain-specific models, and (3) a summary module synthesizing the final summary with visual interpretation maps. Extensive experiments on multi-modal WSI benchmarks show WSI-Agents's superiority to current WSI MLLMs and medical agent frameworks across diverse tasks.

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Xinheng Lyu, Yuci Liang, Wenting Chen, Meidan Ding, Jiaqi Yang, Guolin Huang, Daokun Zhang, Xiangjian He, Linlin Shen. 2025-07-19. WSI-Agents: A Collaborative Multi-Agent System for Multi-Modal Whole Slide Image Analysis. https://arxiv.org/abs/2507.14680

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