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arXiv · 2507.18112

Parameter-Efficient Fine-Tuning of 3D DDPM for MRI Image Generation Using Tensor Networks

Binghua Li·Ziqing Chang·Tong Liang·Chao Li·Toshihisa Tanaka·Shigeki Aoki·Qibin Zhao·Zhe Sun
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Abstract

We address the challenge of parameter-efficient fine-tuning (PEFT) for three-dimensional (3D) U-Net-based denoising diffusion probabilistic models (DDPMs) in magnetic resonance imaging (MRI) image generation. Despite its practical significance, research on parameter-efficient representations of 3D convolution operations remains limited. To bridge this gap, we propose Tensor Volumetric Operator (TenVOO), a novel PEFT method specifically designed for fine-tuning DDPMs with 3D convolutional backbones. Leveraging tensor network modeling, TenVOO represents 3D convolution kernels with lower-dimensional tensors, effectively capturing complex spatial dependencies during fine-tuning with few parameters. We evaluate TenVOO on three downstream brain MRI datasets-ADNI, PPMI, and BraTS2021-by fine-tuning a DDPM pretrained on 59,830 T1-weighted brain MRI scans from the UK Biobank. Our results demonstrate that TenVOO achieves state-of-the-art performance in multi-scale structural similarity index measure (MS-SSIM), outperforming existing approaches in capturing spatial dependencies while requiring only 0.3% of the trainable parameters of the original model. Our code is available at: https://github.com/xiaovhua/tenvoo

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Binghua Li, Ziqing Chang, Tong Liang, Chao Li, Toshihisa Tanaka, Shigeki Aoki, Qibin Zhao, Zhe Sun. 2025-07-24. Parameter-Efficient Fine-Tuning of 3D DDPM for MRI Image Generation Using Tensor Networks. https://arxiv.org/abs/2507.18112

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