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arXiv · 2508.02621

HealthFlow: A Self-Evolving AI Agent with Meta Planning for Autonomous Healthcare Research

Yinghao Zhu·Yifan Qi·Zixiang Wang·Lei Gu·Dehao Sui·Haoran Hu·Xichen Zhang·Ziyi He·Junjun He·Liantao Ma·Lequan Yu
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Abstract

The rapid proliferation of scientific knowledge presents a grand challenge: transforming this vast repository of information into an active engine for discovery, especially in high-stakes domains like healthcare. Current AI agents, however, are constrained by static, predefined strategies, limiting their ability to navigate the complex, evolving ecosystem of scientific research. This paper introduces HealthFlow, a self-evolving AI agent that overcomes this limitation through a novel meta-level evolution mechanism. HealthFlow autonomously refines its high-level problem-solving policies by distilling procedural successes and failures into a durable, structured knowledge base, enabling it to learn not just how to use tools, but how to strategize. To anchor our research and provide a community resource, we introduce EHRFlowBench, a new benchmark featuring complex health data analysis tasks systematically derived from peer-reviewed scientific literature. Our experiments demonstrate that HealthFlow's self-evolving approach significantly outperforms state-of-the-art agent frameworks. This work offers a new paradigm for intelligent systems that can learn to operationalize the procedural knowledge embedded in scientific content, marking a critical step toward more autonomous and effective AI for healthcare scientific discovery.

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Yinghao Zhu, Yifan Qi, Zixiang Wang, Lei Gu, Dehao Sui, Haoran Hu, Xichen Zhang, Ziyi He, Junjun He, Liantao Ma, Lequan Yu. 2025-10-11. HealthFlow: A Self-Evolving AI Agent with Meta Planning for Autonomous Healthcare Research. https://arxiv.org/abs/2508.02621

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