T2 Radiomic Features Are More Sensitive Than Mean T2 for Cartilage Load Response: A Stress MRI Study

Teresa Lemainque; Philipp Schad; Simon Westfechtel; Marc von der Stück; Robert Siepmann; Axel Honné; Christiane Kuhl; Daniel Truhn; Sven Nebelung

arXiv · 2508.15309

T2 Radiomic Features Are More Sensitive Than Mean T2 for Cartilage Load Response: A Stress MRI Study

Teresa Lemainque·Philipp Schad·Simon Westfechtel·Marc von der Stück·Robert Siepmann·Axel Honné·Christiane Kuhl·Daniel Truhn·Sven Nebelung

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Abstract

Objective: To assess response-to-loading in a human cadaveric knee joint model under different loading conditions before and after meniscectomy Design: In this prospective study, stress magnetic resonance imaging was performed using an MR-compatible loading device and quantitative T2 mapping in unloaded (UL), 0$°$ neutrally loaded (LN) and 10$°$ varus loaded (LV) condition before and after meniscectomy. Mean T2 values and four radiomic texture parameters were assessed within the cartilage of medial femur (MF) and medial tibia (MT) for all conditions. Results: Medial joint space width decreased from UL to LN to LV and after meniscectomy (all p<0.05). T2 values did not show any significant dependency on pressure or meniscectomy (all p>0.05). The radiomic parameter variance could assess loading induced textural T2 changes in the MF (UL vs. LN: p=0.042; UL vs. LV: p<0.001; LN vs. LV: p=0.022), and, in part, in the MT (LN vs. LV: p<0.013). Meniscectomy did not significantly alter the T2 mean values or radiomic parameters, respectively. Conclusions: T2-based radiomic features were more sensitive to assess cartilage response to loading than T2-mapping alone.

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Teresa Lemainque, Philipp Schad, Simon Westfechtel, Marc von der Stück, Robert Siepmann, Axel Honné, Christiane Kuhl, Daniel Truhn, Sven Nebelung. 2025-08-21. T2 Radiomic Features Are More Sensitive Than Mean T2 for Cartilage Load Response: A Stress MRI Study. https://arxiv.org/abs/2508.15309

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