Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses

Elisabeth Erbes; Naireeta Biswas; Calvin J. Gavilett; Matthias Schwartzkopf; Krishnayan Basuroy; Qing Chen; Andrei Chumakov; Susann Frenzke; Marc Gensch; Korneliya Goordeyeva; Patrycja Kielb; Sonja Kirchner; Volker Körstgens; Peter Müller-Buschbaum; Henrike M. Müller-Werkmeister; Jan Rubeck; Sreevidya Thekku Veedu; Jose de Jesus Velazquez-Garcia; Vivian Waclawek; Daniel Söderberg; Stephan V. Roth; Simone Techert

arXiv · 2509.08019

Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses

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Abstract

A novel concept of nano-scaled interwoven templates for drug delivery with alternating hydro- and lipophilicity properties is introduced. They are built from cellulose and peptide hydrogel in tandem, and characterized by a nano-stacked interwoven design, thus enabling for tuning the lipophilicity in the mesh nano-domains in which drug candidates of complementary lipophilicities can be embedded. This allows for low-dose-controlled consumption and therapeutic applications. Time-resolved and in-situ grazing incidence X-ray scattering studies confirm the design of the therapeutic nano-paper and create conditions suitable for the drug storage of complementary properties. The molecular design has the potential of a locally controlled, site-specific drug release on a beyond-nanomolar scale. Generalized, the design may contribute to facile developments of personalized medicine.

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Elisabeth Erbes, Naireeta Biswas, Calvin J. Gavilett, Matthias Schwartzkopf, Krishnayan Basuroy, Qing Chen, Andrei Chumakov, Susann Frenzke, Marc Gensch, Korneliya Goordeyeva, Patrycja Kielb, Sonja Kirchner, Volker Körstgens, Peter Müller-Buschbaum, Henrike M. Müller-Werkmeister, Jan Rubeck, Sreevidya Thekku Veedu, Jose de Jesus Velazquez-Garcia, Vivian Waclawek, Daniel Söderberg, Stephan V. Roth, Simone Techert. 2025-09-09. Molecular-Size Control of Properties of Therapeutic Nano-Paper Allows for Selective Drug Storage in Small Doses. https://arxiv.org/abs/2509.08019

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