Grounding Large Language Models in Clinical Evidence: A Retrieval-Augmented Generation System for Querying UK NICE Clinical Guidelines

Matthew Lewis; Samuel Thio; Amy Roberts; Catherine Siju; Whoasif Mukit; Rebecca Kuruvilla; Zhangshu Joshua Jiang; Niko Möller-Grell; Aditya Borakati; Richard JB Dobson; Spiros Denaxas

arXiv · 2510.02967

Grounding Large Language Models in Clinical Evidence: A Retrieval-Augmented Generation System for Querying UK NICE Clinical Guidelines

Matthew Lewis·Samuel Thio·Amy Roberts·Catherine Siju·Whoasif Mukit·Rebecca Kuruvilla·Zhangshu Joshua Jiang·Niko Möller-Grell·Aditya Borakati·Richard JB Dobson·Spiros Denaxas

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Abstract

This paper presents the development and evaluation of a Retrieval-Augmented Generation (RAG) system for querying the United Kingdom's National Institute for Health and Care Excellence (NICE) clinical guidelines using Large Language Models (LLMs). The extensive length and volume of these guidelines can impede their utilisation within a time-constrained healthcare system, a challenge this project addresses through the creation of a system capable of providing users with precisely matched information in response to natural language queries. The system's retrieval architecture, composed of a hybrid embedding mechanism, was evaluated against a corpus of 10,195 text chunks derived from three hundred guidelines. It demonstrates high performance, with a Mean Reciprocal Rank (MRR) of 0.814, a Recall of 81% at the first chunk and of 99.1% within the top ten retrieved chunks, when evaluated on 7901 queries. The most significant impact of the RAG system was observed during the generation phase. When evaluated on a manually curated dataset of seventy question-answer pairs, RAG-enhanced models showed substantial gains in performance. Faithfulness, the measure of whether an answer is supported by the source text, was increased by 64.7 percentage points to 99.5% for the RAG-enhanced O4-Mini model and significantly outperformed the medical-focused Meditron3-8B LLM, which scored 43%. Clinical evaluation by seven Subject Matter Experts (SMEs) further validated these findings, with GPT-4.1 achieving 98.7% accuracy while reducing unsafe responses by 67% compared to O4-Mini (from 3.0 to 1.0 per evaluator). This study thus establishes RAG as an effective, reliable, and scalable approach for applying generative AI in healthcare, enabling cost-effective access to medical guidelines.

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Matthew Lewis, Samuel Thio, Amy Roberts, Catherine Siju, Whoasif Mukit, Rebecca Kuruvilla, Zhangshu Joshua Jiang, Niko Möller-Grell, Aditya Borakati, Richard JB Dobson, Spiros Denaxas. 2025-12-14. Grounding Large Language Models in Clinical Evidence: A Retrieval-Augmented Generation System for Querying UK NICE Clinical Guidelines. https://arxiv.org/abs/2510.02967

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