Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2510.21779

What Causes Postoperative Aspiration?

Supriya Nagesh·Karina Covarrubias·Robert El-Kareh·Shiva Prasad Kasiviswanathan·Nina Mishra
View original source ↗Read source document ↗Export metadata ↓

Abstract

Background: Aspiration, the inhalation of foreign material into the lungs, significantly impacts surgical patient morbidity and mortality. This study develops a machine learning (ML) model to predict postoperative aspiration, enabling timely preventative interventions. Methods: From the MIMIC-IV database of over 400,000 hospital admissions, we identified 826 surgical patients (mean age: 62, 55.7\% male) who experienced aspiration within seven days post-surgery, along with a matched non-aspiration cohort. Three ML models: XGBoost, Multilayer Perceptron, and Random Forest were trained using pre-surgical hospitalization data to predict postoperative aspiration. To investigate causation, we estimated Average Treatment Effects (ATE) using Augmented Inverse Probability Weighting. Results: Our ML model achieved an AUROC of 0.86 and 77.3\% sensitivity on a held-out test set. Maximum daily opioid dose, length of stay, and patient age emerged as the most important predictors. ATE analysis identified significant causative factors: opioids (0.25 +/- 0.06) and operative site (neck: 0.20 +/- 0.13, head: 0.19 +/- 0.13). Despite equal surgery rates across genders, men were 1.5 times more likely to aspirate and received 27\% higher maximum daily opioid dosages compared to women. Conclusion: ML models can effectively predict postoperative aspiration risk, enabling targeted preventative measures. Maximum daily opioid dosage and operative site significantly influence aspiration risk. The gender disparity in both opioid administration and aspiration rates warrants further investigation. These findings have important implications for improving postoperative care protocols and aspiration prevention strategies.

Explore related subjects

cs.LGcs.AI

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Supriya Nagesh, Karina Covarrubias, Robert El-Kareh, Shiva Prasad Kasiviswanathan, Nina Mishra. 2025-10-28. What Causes Postoperative Aspiration?. https://arxiv.org/abs/2510.21779

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Analysis of Regularized Learning in Banach Spaces for Linear-functional Data

This article delves into the study of the theory of regularized learning in Banach spaces for linear-functional data. It encompasses discussions on representer theorems, pseudo-approximation theorems, and convergence theorems. Regularized learning is designed to minimize regularized empirical risks over a Banach space. The empirical risks are calculated by utilizing training data and multi-loss functions. The input training data are composed of linear functionals in a predual space of the Banach space to capture discrete local information from multimodal data and multiscale models. Through the regularized learning, approximations of the exact solution to an unidentified or uncertain original problem are globally achieved. In the convergence theorems, the convergence of the approximate solutions to the exact solution is established through the utilization of the weak* topology of the Banach space. The theorems of regularized learning are utilized in the interpretation of classical machine learning, such as support vector machines and artificial neural networks.

cs.LG↗
arXiv2026

On Minimal Depth in Neural Networks

Understanding the relationship between the depth of a neural network and its representational capacity is a central problem in deep learning theory. In this work, we develop a geometric framework to analyze the expressivity of ReLU networks with the notion of depth complexity for convex polytopes. The depth of a polytope recursively quantifies the number of alternating convex hull and Minkowski sum operations required to construct it. This geometric perspective serves as a rigorous tool for deriving depth lower bounds and understanding the structural limits of deep neural architectures. We establish lower and upper bounds on the depth of polytopes, as well as tight bounds for classical families. These results yield two main consequences. First, we provide a purely geometric proof of the expressivity bound by Arora et al. (2018), confirming that $\lceil \log_2(n+1)\rceil$ hidden layers suffice to represent any continuous piecewise linear (CPWL) function. Second, we prove that, unlike general ReLU networks, convex polytopes do not admit a universal depth bound. Specifically, the depth of cyclic polytopes in dimensions $n \geq 4$ grows unboundedly with the number of vertices. This result implies that Input Convex Neural Networks (ICNNs) cannot represent all convex CPWL functions with a fixed depth, revealing a sharp separation in expressivity between ICNNs and standard ReLU networks.

cs.LG↗
arXiv2026

DeepSPoC: A Deep Learning Based Sequential Propagation of Chaos

Classical particle methods based on propagation of chaos (PoC) have been developed for solving mean-field stochastic differential equations and their associated nonlinear Fokker--Planck equations. However, direct PoC implementations are difficult to apply to high-dimensional problems because they require simulating and storing large numbers of interacting particles, often with high particle-particle interaction costs. Motivated by these limitations, we build on the recently proposed sequential propagation of chaos (SPoC) framework, which replaces the fully interacting particle system in PoC with a sequential interaction mechanism. Based on this structure, we present DeepSPoC, a neural particle method that embeds a neural density representation into the sequential particle dynamics. DeepSPoC simulates particles batch by batch, while the neural network represents the evolving empirical law and is substituted into the coefficients of the mean-field SDE, thereby replacing direct particle-particle interactions with particle-network interactions. In DeepSPoC, a recently developed normalizing flow model called KRnet is used to approximate the empirical measure of particles. Compared with direct particle implementations, DeepSPoC substantially reduces memory consumption and evaluates interaction terms more efficiently, thereby improving scalability for high-dimensional problems. We apply DeepSPoC to a wide range of mean-field equations and verify its effectiveness and computational advantages.

cs.LG↗