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arXiv · 2511.01947

Interpretable Heart Disease Prediction via a Weighted Ensemble Model: A Large-Scale Study with SHAP and Surrogate Decision Trees

Md Abrar Hasnat·Md Jobayer·Md. Mehedi Hasan Shawon·Md. Golam Rabiul Alam
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Abstract

Cardiovascular disease (CVD) remains a critical global health concern, demanding reliable and interpretable predictive models for early risk assessment. This study presents a large-scale analysis using the Heart Disease Health Indicators Dataset, developing a strategically weighted ensemble model that combines tree-based methods (LightGBM, XGBoost) with a Convolutional Neural Network (CNN) to predict CVD risk. The model was trained on a preprocessed dataset of 229,781 patients where the inherent class imbalance was managed through strategic weighting and feature engineering enhanced the original 22 features to 25. The final ensemble achieves a statistically significant improvement over the best individual model, with a Test AUC of 0.8371 (p=0.003) and is particularly suited for screening with a high recall of 80.0%. To provide transparency and clinical interpretability, surrogate decision trees and SHapley Additive exPlanations (SHAP) are used. The proposed model delivers a combination of robust predictive performance and clinical transparency by blending diverse learning architectures and incorporating explainability through SHAP and surrogate decision trees, making it a strong candidate for real-world deployment in public health screening.

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Md Abrar Hasnat, Md Jobayer, Md. Mehedi Hasan Shawon, Md. Golam Rabiul Alam. 2025-11-03. Interpretable Heart Disease Prediction via a Weighted Ensemble Model: A Large-Scale Study with SHAP and Surrogate Decision Trees. https://arxiv.org/abs/2511.01947

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