MambaFormer: Token-Level Guided Routing Mixture-of-Experts for Accurate and Efficient Clinical Assistance

Abstract

The deployment of large language models (LLMs) in real-world clinical applications is constrained by the fundamental trade-off between computational cost and the efficiency of linear-time models. To address this, we propose an LLM-based MambaFormer hybrid Mixture-of-Experts (MoE) framework for efficient medical question-answering (QA) and clinical assistance. The MambaFormer employs a lightweight gating mechanism that performs token-level dynamic routing to a customized Transformer expert (ET5) for short, complex queries or to a State Space Model expert (EMamba) for long, high-throughput sequences. The customized EMamba and ET5 models are tailored to accommodate input sequence dimensionality, embedding structure, sequence length, and target-specific output heads, and are fine-tuned through transfer learning on a new, custom-designed DentalQA dataset. Moreover, intelligent routing decisions are driven by the contextual complexity of token embeddings, normalized sequence length, and domain-aware features, thereby enforcing a Pareto-optimal trade-off between inference latency and prediction accuracy. Furthermore, a novel utility-guided multi-objective loss jointly optimizes decisions, router parameters, routing behavior, expert utilization, and computational cost by adaptively regulating token-level expert activation. Finally, the proposed MambaFormer is cross-validated (holdout) for medical QA on the new, custom-designed DentalQA and PubMedQA datasets and compared with state-of-the-art techniques. The proposed MambaFormer outperforms (BERTScore = 0.9180) with ultra-low latency (0.077 s), delivering a 24.4 speedup over T5-Large and establishing a scalable solution for resource-constrained clinical deployment.