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arXiv · 2607.05055

Toward Trustworthy Large Language Model Agents in Healthcare

Hadi Hasan·Safaa Salman·Adam Tai Abou Dargham·Ammar Mohanna·Ali Chehab
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Abstract

Healthcare appointment scheduling remains a persistent operational bottleneck, driven by manual coordination, fragmented legacy systems, and high administrative overhead. These inefficiencies constrain provider availability and degrade patient access to care. This paper presents CareConnect, a safety-first conversational agent for healthcare logistics automation that leverages large language model (LLM) function calling, retrieval-augmented generation (RAG), and layered deterministic safety guardrails. The system orchestrates eight domain-specific tools to support appointment booking, modification, cancellation, and facility information retrieval, while enforcing strict scope constraints that prohibit medical advice or diagnosis. Safety-critical situations are handled through deterministic short-circuit mechanisms for emergency detection and medical intent refusal. We evaluate CareConnect on a comprehensive benchmark of 680 task-oriented scenarios spanning end-to-end workflows, multi-turn interactions, and edge cases. Experimental results demonstrate a 91.8% task completion rate with a median per-request latency of 2.2 seconds, 96.0% safety compliance on the dedicated safety-critical evaluation subset, and an average operational cost of $0.0324 per appointment, yielding a significant cost reduction compared to manual human scheduling. These findings show that carefully scoped and rigorously safeguarded LLM-based agents can reliably automate complex healthcare operational workflows while maintaining safety guarantees and achieving substantial cost efficiency. The source code and system implementation are publicly available at https://github.com/Hadi-Hsn/CareConnect.

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Hadi Hasan, Safaa Salman, Adam Tai Abou Dargham, Ammar Mohanna, Ali Chehab. 2026-07-06. Toward Trustworthy Large Language Model Agents in Healthcare. https://arxiv.org/abs/2607.05055

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