Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2608.25109

Improving Cross-Site Whole-Heart Segmentation

Tanish Mudaliar·Justin Li·Daniel Lin·Julianna Vo·Kaitao Liao·Xin Wang·Shu Hu
View original source ↗Read source document ↗Export metadata ↓

Abstract

Whole-heart segmentation from CT and MRI is essential for quantitative cardiac image analysis, but remains challenging under multi-center and multi-modality distribution shift. In the CARE whole-heart segmentation task, models must generalize from limited labeled sites to unseen acquisition distributions, where variation in spacing, intensity, reconstruction texture, and anatomy can degrade out-of-distribution performance. We propose a modality-routed 3D cardiac segmentation pipeline that combines TotalSegmentator-initialized nnU-Netv2 models with site-characterized, label-preserving appearance augmentation. We first characterize the available sites using measurable image properties and use this analysis to motivate candidate data-space generalization routes. The final retained recipe applies Bias Field + Bezier appearance augmentation, combining smooth spatial intensity perturbation with nonlinear intensity remapping, followed by lightweight class-wise largest-connected-component cleanup. On the primary held-out-site validation splits, the final configuration improves CT mean Dice from 0.8350 to 0.9135 and MRI mean Dice from 0.7695 to 0.7830, while also reducing HD95. These results suggest that site-motivated appearance augmentation is a practical strategy for improving cross-site robustness in limited-data whole-heart segmentation. Our code can be found in https://github.com/Purdue-M2/Improving-Cross-Site-Whole-Heart-Segmentation

Explore related subjects

eess.IVcs.CV

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Tanish Mudaliar, Justin Li, Daniel Lin, Julianna Vo, Kaitao Liao, Xin Wang, Shu Hu. 2026-08-25. Improving Cross-Site Whole-Heart Segmentation. https://arxiv.org/abs/2608.25109

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Bridging the Inter-Domain Gap through Low-Level Features for Cross-Modal Medical Image Segmentation

This paper addresses cross-modal medical image segmentation, focusing on MRI-CT transfer in a source-only domain generalization setting. During training, only source-modality samples are available, while unlabeled target-modality images are used for testing. We propose LowBridge, which builds on the observation that cross-modal images share similar low-level features (e.g. edges) as they depict the same types of anatomical structures. Specifically, we first train a generative model to recover the source images from their edge features, followed by training a segmentation model on the generated source images, separately. At test time, edge features from the target images are input to the pretrained generative model to generate source-style target domain images, which are then segmented using the pretrained segmentation network. Experiments on various public datasets demonstrate that LowBridge achieves state-of-the-art performance, outperforming ten existing approaches. Ablation studies further show that LowBridge is compatible with different types of generative and segmentation models, suggesting its generalizability and potential to benefit from future advances in these models. The code will be available at https://github.com/JoshuaLPF/LowBridge.

eess.IV↗
arXiv2026

Revolutionizing Diffusion MRI Microstructure Mapping via Global Inversion

Diffusion MRI microstructure mapping (MM) is conventionally solved voxel by voxel, ignoring the fact that tissue microstructure forms a spatially organized field. This isolation leaves each estimation problem ill-posed and nonconvex. We instead cast MM as a single global inverse problem, reconstructing the entire parameter field jointly from all measurements of a subject. An untrained neural representation supplies implicit spatial priors and eases the nonconvex optimization, requiring no training data, while coregistered T1-weighted anatomy contributes structural guidance that is freely available in standard protocols. On both synthetic and in-vivo data, our method compares favorably with established voxel-wise and learning-based baselines, suggesting global inversion is a promising alternative.

eess.IV↗
arXiv2026

LC3EM: Long-Range Context Extrapolation Enhanced Entropy Model for Coordinate-based Overfitting Image Codecs

Coordinate-based overfitting image codecs have attracted increasing attention for their low decoding complexity and independence from cross-image generalization. However, representative approaches such as COOL-CHIC face an inherent entropy-modeling trade-off: lightweight models have limited capacity, while more expressive ones incur additional bitrate overhead from transmitting image-specific parameters. Inspired by the prediction mechanism in traditional codecs, we propose a new entropy-modeling strategy that introduces complementary prediction modes with region-adaptive soft mode selection, rather than relying on a single learned predictor to model diverse types of redundancy. Based on this concept, we develop a Long-Range Context Extrapolation Enhanced Entropy Model (LC3EM), which can be integrated into coordinate-based overfitting codecs. Specifically, a parameter-free Neighborhood-based Linear Extrapolation Mode (NLEM) complements the tiny MLP-based local predictor to exploit long-range contextual redundancy and strongly directional structures. A Minimum-Entropy-Inspired Continuous Mode Selection strategy is designed to adaptively fuse these two complementary modes, while requiring the transmission of only the parameters of a single additional linear layer. Moreover, to alleviate the mismatch between training-time relaxed and actual discrete quantization, we introduce a lightweight iterative latent rounding refinement stage to improve compression performance. Experiments demonstrate consistent improvements across diverse benchmarks, particularly on highly regular computer-generated images. When integrated with COOL-CHIC 4.0, the proposed method achieves BD-rate gains of -3.43\% and -7.69\% on the SIQAD and API datasets, respectively. With COOL-CHIC 5.0 as the backbone, the corresponding gains are -2.88\% and -3.15\%, respectively. The code will be made publicly available soon.

eess.IV↗