Search arXiv⌕ Search
Home/Archive/arXiv

arXiv · 2609.11493

From Document Silos to Process Intelligence: A Multi-Layer Knowledge Graph for CMC Process Development

Reza Amirmoshiri·Faryad Sahneh·Yasser Jangjou
View original source ↗Read source document ↗Export metadata ↓

Abstract

Chemistry, Manufacturing and Controls (CMC) process development generates an enormous body of technical information across a multi-stage, knowledge-intensive continuum from drug discovery to commercial manufacturing. This knowledge is traditionally fragmented across functions and heterogeneous formats, causing traceability gaps and significant knowledge-management costs during technology transfer and regulatory filing. We present a modular agentic-AI platform that converts a heterogeneous corpus of process-development documents into a queryable, dual-layer knowledge graph. A base knowledge layer builds a lexical graph with a Document-Section-Chunk hierarchy through lossless ingestion of digital, scanned, handwritten, and multilingual documents, while an intelligence layer extracts ontology-aligned entities and bridges cross-document concepts through a provenance-anchored domain graph. LLM agents operate across both layers, selecting the retrieval path best suited to each question. We evaluate the lexical layer with a novel three-tier protocol measuring the deployment-fidelity of a retrieval-augmented generation (RAG) system on proprietary data, demonstrated on 505 questions curated from 38 development reports of a Sanofi small-molecule program. Tier-1 multiple-choice accuracy of 95% signals strong platform reliability; the stricter Tier-2 LLM-judge pass rate of 85%, which degrades on comparative and corpus-wide questions, reveals a failure taxonomy that Tier-1 accuracy alone fails to capture. A router agent selects between layers according to question type. We anticipate this protocol will enable future designers of agentic platforms to assess their systems against nonpublic databases, and that graph-based architectures will see broader adoption in pharma as a means of transforming fragmented document repositories into structured process intelligence.

Explore related subjects

cs.AIcs.MA

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Reza Amirmoshiri, Faryad Sahneh, Yasser Jangjou. 2026-09-23. From Document Silos to Process Intelligence: A Multi-Layer Knowledge Graph for CMC Process Development. https://arxiv.org/abs/2609.11493

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Generating Interesting Scientific Ideas using Knowledge Graphs and LLMs: Evaluations with 100 Research Group Leaders

The rapid growth of scientific literature makes it increasingly challenging for researchers to identify novel and impactful ideas, especially across disciplines. Modern artificial intelligence (AI) systems offer new opportunities for scientific ideation, but how compelling are AI-generated ideas, and how can their quality be improved? Here, we introduce SciMuse, which generates personalized research ideas using a knowledge graph of 58 million papers and a large language model (LLM). A central focus of this work is to understand how interesting these ideas are. Therefore, we conducted a large-scale evaluation in which more than 100 research group leaders -- spanning the natural sciences to the humanities -- rated over 4,400 personalized ideas according to their level of interest. Overall, expert ratings were modest (mean 2.40 on a 5-point scale, most common rating 1), while 24.9% of ideas were rated 4 or 5. We find that supplying concept pairs selected using the knowledge graph does not improve expert-rated interest over a titles-only GPT baseline. High-citation-predicted pairs even showed a weak tendency (1.94$σ$) toward lower interest than random pairs. Nevertheless, graph features can be used to control properties of ideas, and, using this unique evaluation dataset, we show that idea interest can be predicted with both a supervised neural network based on graph features and a zero-shot ranking approach based on an LLM. Our work provides an AI methodology for generating scientific ideas and a large-scale interdisciplinary expert evaluation, paving the way to study and improve difficult-to-measure metrics such as expert-perceived scientific interestingness.

cs.AI↗
arXiv2026

LOGIC: Efficient and Robust Contextual Biasing for Speech LLMs via Logit-Space Integration

Recognizing entity phrases remains a critical challenge for speech large language models. Existing prompting methods lack an explicit decoding-time biasing weight, limiting their controllability. Generative error correction methods can introduce hallucinated over-corrections. To address these limitations, we propose LOGIC (logit-space integration for contextual biasing), a robust framework operating directly in the logit space. By decoupling context injection from input processing, LOGIC enables explicit control over the biasing strength. Extensive experiments with an open-source speech large language model across 11 locales demonstrate that LOGIC achieves an average 9% relative reduction in entity word error rate, with an average false alarm rate increase of 0.3% and a 2.8% relative runtime overhead. When combined with prompting, LOGIC can reduce entity word error rate by 5% relative to the prompt-only method.

cs.AI↗
arXiv2026

Decoding ML Decision: An Agentic Reasoning Framework for Large-Scale Ranking System

Modern large-scale ranking systems operate within a sophisticated landscape of competing objectives, operational constraints, and evolving product requirements. Progress in this domain is increasingly bottlenecked by the engineering context constraint: the arduous process of translating ambiguous product intent into reasonable, executable, verifiable hypotheses, rather than by modeling techniques alone. We present GEARS (Generative Engine for Agentic Ranking Systems), a framework that reframes ranking optimization as an autonomous discovery process within a programmable experimentation environment. Rather than treating optimization as static model selection, GEARS leverages Specialized Agent Skills to encapsulate ranking expert knowledge into reusable reasoning capabilities, enabling operators to steer systems via high-level intent vibe personalization. Furthermore, to ensure production reliability, the framework incorporates validation hooks to enforce statistical robustness and filter out brittle policies that overfit short-term signals. Experimental validation across diverse product surfaces demonstrates that GEARS consistently identifies superior, near-Pareto-efficient policies by synergizing algorithmic signals with deep ranking context while maintaining rigorous deployment stability.

cs.AI↗