From the Drosophila Visual Connectome to General-Purpose Computer Vision

Zongyu Li; Akito Yamauchi; Huaizhi Liu; Vishwanatha Rao; Jia Guo; for the Frontotemporal Lobar Degeneration Neuroimaging Initiative; for the Alzheimer's Disease Neuroimaging Initiative

arXiv · 2610.08418

From the Drosophila Visual Connectome to General-Purpose Computer Vision

Zongyu Li·Akito Yamauchi·Huaizhi Liu·Vishwanatha Rao·Jia Guo·for the Frontotemporal Lobar Degeneration Neuroimaging Initiative·for the Alzheimer's Disease Neuroimaging Initiative

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Abstract

Biological connectomes encode structured solutions to visual computation that may provide reusable inductive biases for artificial vision. We develop ConnectomeX around FlyVision, a trainable architecture that preserves parallel ON/OFF processing, recurrent computation and population-level graph interaction while scaling model capacity across tasks. FlyVision reached 99.34% accuracy on MNIST with 80,608 parameters and 78.03% on CIFAR-10 with 81,408 parameters. On ImageNet-1K, FlyVision Base and Large reached 60.79% and 66.25% top-1 accuracy with 1.8 and 3.7 million parameters, while a Large local-k7 model with a learned low-frequency branch reached 66.53%, compared with 69.25% for ResNet18 with 11.7 million parameters. On a 22-class skin-disease benchmark, FlyVision Large achieved 63.78% accuracy and 95.28% macro-AUROC with 2.99 million parameters. In four-class chest radiography, ImageNet-pretrained FlyVision Base and Large reached 92.60% and 92.76% accuracy with 1.33 and 2.97 million parameters, compared with 91.56% for ImageNet-pretrained ResNet18 with 11.18 million. BrainAGE extends FlyVision to volumetric T1-weighted MRI by applying a shared ImageNet-pretrained FlyVision Large encoder to 24 sagittal, coronal and axial slices per scan and combining slice-level age estimates by confidence-modulated Gaussian voting. On 433 held-out scans, three-axis fusion achieved a mean absolute error of 5.98 years and R^2 = 0.868. Across the 224x224 classification tasks, the best FlyVision configuration remained within three percentage points of ResNet18 on ImageNet-1K and skin-disease classification and exceeded it on chest radiography with substantially fewer parameters. These results show that a conserved connectome-informed computation can scale from compact recognition to large-scale natural and biomedical vision.

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Zongyu Li, Akito Yamauchi, Huaizhi Liu, Vishwanatha Rao, Jia Guo, for the Frontotemporal Lobar Degeneration Neuroimaging Initiative, for the Alzheimer's Disease Neuroimaging Initiative. 2026-10-06. From the Drosophila Visual Connectome to General-Purpose Computer Vision. https://arxiv.org/abs/2610.08418

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