Evidence-Anchored Overdose Death Prediction from Death Investigation Reports

Raavi Gupta; Ziqing Yang; Karli R. Hochstatter; Talia Nadel; Nicole D'Anna; Jason K. Graham; Hannah Johnson; Kelsey Opozda; Nabila El-Bassel; Anubhav Jangra; Smaranda Muresan

arXiv · 2610.19556

Evidence-Anchored Overdose Death Prediction from Death Investigation Reports

Raavi Gupta·Ziqing Yang·Karli R. Hochstatter·Talia Nadel·Nicole D'Anna·Jason K. Graham·Hannah Johnson·Kelsey Opozda·Nabila El-Bassel·Anubhav Jangra·Smaranda Muresan

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Abstract

Confirmation of overdose deaths in the United States is often delayed due to the complexities of certifying drug-involved deaths. Death investigation reports represent a rich but underutilized data source that could be used to predict whether a death is a suspected overdose (i.e., a death preliminarily identified as an overdose prior to the final cause and manner of death determination). We present an automated framework that classifies suspected overdoses from death investigation reports, while producing supporting explanations guided by expert knowledge. Through an expert-guided design process, we investigate 1) what type of explanations are best for model prediction performance, and 2) which architecture is better suited for this task: pipeline models that rationalize first and then predict, or self-rationalizing models that jointly predict and rationalize? Our experiments show that a pipeline model with explanations grounded in the input death investigation reports outperforms the other settings. Our best model also outperforms a rule-based system currently in deployment by 15%, while allowing expert interventions for final decisions.

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Raavi Gupta, Ziqing Yang, Karli R. Hochstatter, Talia Nadel, Nicole D'Anna, Jason K. Graham, Hannah Johnson, Kelsey Opozda, Nabila El-Bassel, Anubhav Jangra, Smaranda Muresan. 2026-10-14. Evidence-Anchored Overdose Death Prediction from Death Investigation Reports. https://arxiv.org/abs/2610.19556

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