EGIP: An Evidence-Grounded Interaction Protocol for Clinical Agents

Zecheng Ren; Ruichen Cong; Yi Min Chen; Jing Zhang; Feiyang Chen; Wutong Zhang; Kaixiang Wang; Zihan Wang; Jiong Lou; Jie LI; Qun Jin

arXiv · 2610.24539

EGIP: An Evidence-Grounded Interaction Protocol for Clinical Agents

Zecheng Ren·Ruichen Cong·Yi Min Chen·Jing Zhang·Feiyang Chen·Wutong Zhang·Kaixiang Wang·Zihan Wang·Jiong Lou·Jie LI·Qun Jin

View original source ↗Read source document ↗Export metadata ↓

Abstract

Interactive clinical agents acquire evidence through patient dialogue and diagnostic examinations, yet their performance also depends on how the interaction environment exposes information, available actions, and examination results. When these conditions are implicit or inconsistently controlled, final-answer accuracy can conflate diagnostic reasoning with the effects of the interaction protocol. We propose the \textbf{E}vidence-\textbf{G}rounded \textbf{I}nteraction \textbf{P}rotocol (EGIP), which enforces role-specific information boundaries, exposes diagnostic actions without revealing their results, retrieves examination results from stored clinical records, and organizes acquired evidence for final decision-making. By separating evidence acquisition from terminal prediction, EGIP enables different decision strategies to operate on the same observations. We evaluate EGIP across two clinical-agent frameworks, five datasets, and six language models. EGIP improves diagnostic accuracy over native baselines across all primary comparisons. A clinician review further shows that the proportion of automatically scored correct responses jointly judged evidence-supported rises from 10.20\% to 36.55\%. These findings support the effectiveness of EGIP as a unified interaction protocol for improving clinical-agent performance through controlled evidence access and acquisition.

Explore related subjects

cs.CL

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

Zecheng Ren, Ruichen Cong, Yi Min Chen, Jing Zhang, Feiyang Chen, Wutong Zhang, Kaixiang Wang, Zihan Wang, Jiong Lou, Jie LI, Qun Jin. 2026-10-17. EGIP: An Evidence-Grounded Interaction Protocol for Clinical Agents. https://arxiv.org/abs/2610.24539

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Post-hoc Disentanglement of Textual and Acoustic Features in Pre-trained Speech Encoders

Pre-trained speech models build entangled internal representations, which capture a variety of features (e.g., pitch, loudness, syntax, or semantics of an utterance) in a distributed encoding. This entanglement makes it difficult to track how such representations rely on textual versus acoustic information when used in downstream applications, limiting their interpretability and transparency. In this paper, we explore an approach to post-hoc disentanglement that builds on the Information Bottleneck principle. We take representations from pre-trained speech encoders as input, and separate them into two distinct components in a cascaded fashion: first we learn a vector encoding content (i.e., what can be transcribed as text), and nothing else; second, we learn a vector encoding all complementary acoustic features relevant to a target task. We apply and evaluate our proposed setup to emotion recognition and speaker identification target tasks, quantifying the relative contribution of textual and acoustic features at each model layer. Finally, we use the approach for disentangled feature attribution as it allows us to identify the most salient speech frames from both the textual and acoustic perspectives.

cs.CL↗

arXiv2026

The Super Emotion Dataset

Despite the wide-scale usage and development of emotion classification datasets in NLP, the field lacks a standardized, large-scale resource that follows a psychologically grounded taxonomy. Existing datasets either use inconsistent emotion categories, suffer from limited sample size, or focus on specific domains. The SuperEmotion dataset addresses this gap by harmonizing diverse text sources into a unified framework based on Shaver's empirically validated emotion taxonomy, enabling more consistent cross-domain emotion recognition research. This report describes version 2 of the dataset. We also report baseline results for a fine-tuned ModernBERT encoder.

cs.CL↗

arXiv2026

AutoMind: Adaptive Knowledgeable Agent for Automated Data Science

Large Language Model (LLM) agents have shown great potential in addressing real-world data science problems. LLM-driven data science agents promise to automate the entire machine learning pipeline, yet their real-world effectiveness remains limited. Existing frameworks depend on rigid, pre-defined workflows and inflexible coding strategies; consequently, they excel only on relatively simple, classical problems and fail to capture the empirical expertise that human practitioners bring to complex, innovative tasks. In this work, we introduce AutoMind, an adaptive, knowledgeable LLM-agent framework that overcomes these deficiencies through three key advances: (1) a curated expert knowledge base that grounds the agent in domain expert knowledge, (2) an agentic knowledgeable tree search algorithm that strategically explores possible solutions, and (3) a self-adaptive coding strategy that dynamically tailors code generation to task complexity. Evaluations on two automated data science benchmarks demonstrate that AutoMind delivers superior performance versus state-of-the-art baselines. Additional analyses confirm favorable effectiveness, efficiency, and qualitative solution quality, highlighting AutoMind as an efficient and robust step toward fully automated data science. Code is at https://github.com/zjunlp/AutoMind.

cs.CL↗