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Zihan Wang

Publications and source records attributed to Zihan Wang.

At least 19 recordsLinked to original sources

Multiscale Topology-Regulated Nonlinear Dynamics for Protein B-Factor Prediction and Single-Cell Type Classification

Protein B-factor prediction and single-cell type classification are important for characterizing structural variability and cellular heterogeneity, with applications in biological function analysis and drug discovery. However, static geometric descriptors do not directly capture how multiscale connectivity shapes responses to local perturbations. Here, we introduce multiscale graph-coupled Burgers response learning (MGCBRL), a framework integrating algebraic topology and nonlinear dynamics to construct predictive biological representations. Specifically, a filtration converts protein coordinates or cellular principal component scores into weighted graphs at ten neighborhood scales. Independent unit impulses initiate node-specific responses governed by nonlinear Burgers dynamics. Statistical summaries or sampled source-node trajectories then encode the influence of structural neighborhoods on transient signal evolution. The simulated responses serve as computational probes rather than models of biological motion. For cross-protein prediction, multiscale response statistics are combined with spectral perturbation descriptors measuring changes in Laplacian spectra after node removal. For single-cell classification, principal component scores augment these features to retain explicit expression-space information, and the resulting descriptors support downstream supervised learning. Across 104 proteins and 13 single-cell datasets, MGCBRL achieved configuration-selected mean scores of 0.888 for within-protein Pearson correlation and 0.950 for transductive cell classification balanced accuracy, with leave-one-protein-out mean correlations of 0.496-0.558. Our framework provides a shared strategy for transforming multiscale biological connectivity into informative response descriptors, supporting predictive analysis of protein structures and transcriptomic profiles.

q-bio.QM↗

Memory-Centric Continual Learning for AI Agents

Autonomous agents powered by foundation models can reason, plan, and use tools, but their fixed weights and context limits hinder sustained learning from experience over long-term deployment. While external memory systems attempt to bridge this gap, they mostly act as passive retrieval caches, evaluated primarily by whether they can recall stored facts or past interactions. Whether memory can drive genuine continual learning remains an open question. In this paper, we introduce Memory-Centric Continual Learning (MCCL), arguing that memory should be judged by whether it improves future actions, not merely what it retrieves. MCCL has three main parts. First, a three-axis taxonomy organizes memory by where state is stored (substrates), what form it takes (assets), and how it is managed (policies). This defines a two-loop lifecycle that updates memory state in an inner loop while refining management policies in an outer loop based on task feedback. Second, an evaluation protocol measures retention under interference, adaptation to change, and task transfer to isolate genuine behavioral gains from simple context expansion. Third, a memory scaling framework models how agent performance scales with experience, storage capacity, and compute budgets across non-parametric and parametric memory. Together, these components reframe agent memory from passive lookup to continuous learning, offering a principled route toward self-improving autonomous agents.

cs.CL↗

DONIC: Generalist Dexterous Bimanual Tracking Control from Human Demonstrations

Despite recent progress in dexterous reference tracking, existing models focus primarily on single-hand manipulation and a limited range of interactions, leaving the bimanual dexterous behaviors common in real life unaddressed. The scarcity of contact-rich bimanual manipulation data and the increased complexity of coordinating contacts make developing a generalist bimanual tracker particularly challenging. Therefore, we present 1) DONIC, the first generalist bimanual tracker jointly trained across operation categories and human-motion sources, together with 2) BiHOI, a multi-view dataset of 1,575 sequences spanning 229 objects and emphasizing sustained bimanual interaction, where reconstructed interactions are retargeted into robot references. DONIC combines proximal policy optimization with behavioral cloning in a feedback loop that recycles verified successful executions into training demonstrations. An object-centered per-hand reward maintains object-motion feedback while supervising each hand according to its reference contact role. Clip-Centered Advantages remove reference-dependent advantage offsets while preserving within-trajectory differences. Together, these designs enable one single policy to learn coordinated manipulation across heterogeneous references. Without finetuning, a single checkpoint achieves 86.79% success on unseen trajectories of training objects and 57.32% on held-out objects, surpassing the state-of-the-art bimanual tracking baselines by 77.36 and 45.73 percentage points.

cs.RO↗

Just Initialize: A Training-Free Initialization Component for Large-Scale Routing Optimization

Large-scale routing problems are difficult to solve efficiently as their search spaces grow rapidly with problem size. Existing approaches primarily improve the optimization procedure itself, often at increasing computational cost. We instead shift the focus to a useful initialization that can be refined into a high-quality solution with limited downstream refinement. We propose Just Initialize, a training-free and solver-agnostic initialization component for large-scale routing optimization. Just Initialize compresses a large routing instance into a compact surrogate space, optimizes its global routing structure, and recovers the resulting solution as an optimization-friendly starting point in the original space. Extensive experiments on Traveling Salesman Problems (TSPs), Capacitated Vehicle Routing Problems (CVRPs), Vehicle Routing Problems with Time Windows (VRPTWs), and Prize-Collecting Traveling Salesman Problems (PCTSPs) demonstrate that Just Initialize achieves high-quality solutions comparable to or better than state-of-the-art methods while substantially reducing computational cost across instances ranging from 1K to 100K nodes, including an average speedup of approximately 70$\times$, sub-second runtimes on 10K-node instances, and runtimes within tens of seconds on 100K-node instances.

cs.AI↗

CyberArena: Benchmarking AI Agents in Live Symmetric Attack-and-Defense Combat

AI agents are demonstrating increasingly strong offensive and defensive cybersecurity capabilities in the real world. Current benchmarks mostly evaluate agents in isolation against static targets. Real cyber operations, however, are dynamic and coupled: security postures constantly change as attackers and defenders adapt to each other in real time. Static benchmarks quickly saturate and miss an agent's ability to attack and defend simultaneously under live pressure. To address this gap, we present CyberArena, a dynamic, symmetric adversarial benchmark built around multi-round attack-and-defense combat. In isolated sandboxes, two agents compete under identical rules, acting concurrently as both attackers and defenders over continuously changing services. This converts static targets into evolving, semi-open challenges, directly testing an agent's speed and precision in discovering, exploiting, and patching vulnerabilities. To sustain the benchmark's longevity, an automated agentic pipeline continuously generates, reviews, and validates new environments. Furthermore, because pairwise contests are notoriously hard to quantify, we introduce a dynamical model that maps match dynamics into unified, multidimensional scores across offensive, defensive, and domain-specific capabilities. Evaluating 12 frontier LLM agents across 40 challenges in 466 matches, CyberArena separates model capabilities where single-agent baselines hit a ceiling. The trajectories read like a fight rather than an exam: defenders patch one hole and miss the next and certify repairs on stale evidence, while capable agents think a move ahead, planting backdoors for later rounds and, in one case, writing their own packet sniffer to watch the opponent. Beyond a benchmark, CyberArena serves as an adaptable, scalable experimental platform for future research on cybersecurity agents.

cs.CR↗

Humanity's Last Exam

Benchmarks are important tools for tracking the rapid advancements in large language model (LLM) capabilities. However, benchmarks are not keeping pace in difficulty: LLMs now achieve over 90\% accuracy on popular benchmarks like MMLU, limiting informed measurement of state-of-the-art LLM capabilities. In response, we introduce Humanity's Last Exam (HLE), a multi-modal benchmark at the frontier of human knowledge, designed to be the final closed-ended academic benchmark of its kind with broad subject coverage. HLE consists of 2,500 questions across dozens of subjects, including mathematics, humanities, and the natural sciences. HLE is developed globally by subject-matter experts and consists of multiple-choice and short-answer questions suitable for automated grading. Each question has a known solution that is unambiguous and easily verifiable, but cannot be quickly answered via internet retrieval. State-of-the-art LLMs demonstrate low accuracy and calibration on HLE, highlighting a significant gap between current LLM capabilities and the expert human frontier on closed-ended academic questions. To inform research and policymaking upon a clear understanding of model capabilities, we publicly release HLE at https://lastexam.ai.

cs.LG↗

Orbia: Do Generated Videos Form a Consistent 3D World?

Video generators serve as interactive worlds for exploration and simulation, yet realistic and visually appealing frames do not necessarily depict a consistent 3D world. Existing benchmarks assess selected geometric properties or use vision-language models to judge memory and consistency, leaving systematic 3D evaluation underexplored. We introduce Orbia, the first benchmark dedicated to a systematic and comprehensive evaluation of 3D consistency in interactive world models. Through controlled exploration and revisit, we organize the evaluation into three dimensions: input preservation, generated-content persistence, and 3D self-consistency. For input preservation, registered RGB-D references and annotated anchors support appearance, geometry, and spatial stability measurements. For generated-content persistence, we compare revisits to regions absent from the input image with their first generated observations to test whether models preserve what they create. For 3D self-consistency, cross-view depth and feature correspondence, regional scale agreement, and held-out Gaussian rendering test whether generated views describe the same 3D scene. Minute-long exploration and revisits further test long-term consistency. Our construction and annotation pipeline brings together public datasets, self-captured scenes, and simulation, yielding 720 instances across indoor and outdoor environments and six exploration-and-revisit protocols. Evaluation spans 27 text-, action-, and camera-conditioned models through native-interface adapters. Our Orbia benchmark provides a systematic basis for diagnosing 3D inconsistency and developing more persistent video world models.

cs.CV↗

CasePlay: Self-Play Reinforcement Learning from Case Reports for Medical Reasoning

Reinforcement learning (RL) is a promising way to improve the clinical reasoning abilities of large language models (LLMs), but current pipelines often rely on expert-labeled questions or costly synthetic-data generation. Meanwhile, the medical literature offers a wealth of high-quality unlabeled documents, including clinical case reports that trace the full clinical course from initial presentation to final treatment decisions. We study whether document-grounded self-play can convert these reports into effective RL training signals. We identify two challenges that limit existing self-play methods in this setting: knowledge-point fixation}, where the proposer repeatedly asks about a narrow set of salient clues in a source report, and difficulty-quality mismatch, where appropriately difficult questions may still be poorly formed or shallow, limiting their value for reasoner training. To address these challenges, we propose CasePlay, a self-play framework with two key components: (a) a Knowledge-Conditioned Proposer, which anchors question generation to case-specific knowledge points so that questions draw on a broader range of evidence from the source report; and (b) a Rubric-Judge Reasoner, which augments answer-accuracy feedback with rubric-based quality feedback on clue integration, reasoning depth, and option quality, guiding the proposer toward reasoning-intensive questions that better support reasoner training. Extensive experiments across seven medically related benchmarks demonstrate that CasePlay outperforms existing self-play baselines and improves the SFT warm-start model by 3.1 points on average, highlighted by a 6.3-point gain on LiveClin. This approach offers an effective path toward continually improving medical reasoning ability through self-play RL.

cs.LG↗

EGIP: An Evidence-Grounded Interaction Protocol for Clinical Agents

Interactive clinical agents acquire evidence through patient dialogue and diagnostic examinations, yet their performance also depends on how the interaction environment exposes information, available actions, and examination results. When these conditions are implicit or inconsistently controlled, final-answer accuracy can conflate diagnostic reasoning with the effects of the interaction protocol. We propose the \textbf{E}vidence-\textbf{G}rounded \textbf{I}nteraction \textbf{P}rotocol (EGIP), which enforces role-specific information boundaries, exposes diagnostic actions without revealing their results, retrieves examination results from stored clinical records, and organizes acquired evidence for final decision-making. By separating evidence acquisition from terminal prediction, EGIP enables different decision strategies to operate on the same observations. We evaluate EGIP across two clinical-agent frameworks, five datasets, and six language models. EGIP improves diagnostic accuracy over native baselines across all primary comparisons. A clinician review further shows that the proportion of automatically scored correct responses jointly judged evidence-supported rises from 10.20\% to 36.55\%. These findings support the effectiveness of EGIP as a unified interaction protocol for improving clinical-agent performance through controlled evidence access and acquisition.

cs.CL↗

Learning from Unverified Peers via Shared Residual Distillation

A language model can generate several solutions to the same problem, some leading to correct answers and others to incorrect ones. Many post-training methods turn these trajectories into learning signals using supervision from reference answers, verifiable feedback, or external teachers. Without such supervision, learning from the model's own generations becomes less straightforward, as their correctness cannot be reliably assessed. An incorrect solution may nevertheless contain useful intermediate reasoning, so its value as supervision need not be determined solely by its final answer. Can a model improve by learning from its unverified peer solutions without first determining which are correct? We propose Shared Residual Distillation (SRD), an on-policy self-distillation method that learns from the model's own unverified peer trajectories. SRD compares how peers change the prediction distribution relative to a control, retaining adjustments that agree in direction and are conservative in magnitude. This yields supervision without treating any complete solution as correct, and the trained model requires no peers at inference time. Starting from the corresponding base models, SRD raises mean AIME24--26 avg@12 from 11.02 to 16.20 on Qwen3-1.7B, from 19.07 to 45.46 on Qwen3-4B, and from 21.39 to 54.44 on Qwen3-8B. Controlled ablations support the value of the shared-residual construction, and we observe no degradation relative to the base models on two general-capability benchmarks.

cs.AI↗

Interlock: From Local Correctness to Task Completion in Long-Horizon Agents

Large language model agents increasingly undertake long-horizon tasks in complex environments characterized by fragmented evidence, partially completed states, and dependencies across resources and artifacts. Existing agents may satisfy individual requirements while failing to maintain these relationships, producing locally correct but incomplete outcomes. These failures arise because task completion depends on relationships among environmental evidence, consequential decisions, and required effects. To address this completion gap, we propose Interlock, a framework for task synthesis that represents each task as a typed completion graph. Grounding edges connect public evidence to decisions, coupling hyperedges impose joint constraints across components, and realization edges connect decisions to all required downstream effects. Interlock compiles this graph into a resettable workspace, a public request, and an evaluation rubric. A source-coverage review checks whether the original requirements survive generation, while a public-input review checks whether the rubric is supported by the materials available to the solver. An agent-as-judge inspects execution artifacts and runs verification scripts, retaining trajectories judged to satisfy all mandatory requirements. To evaluate training utility, we fine-tune two Qwen3.6 backbones on their own accepted trajectories. Across the two backbones, training improves AutomationBench task pass rates by 4.00-4.50 percentage points, JobBench weighted scores by 3.20-6.64 points, and Harvey LAB criterion pass rates by 3.89-4.16 percentage points. These results demonstrate the training utility of the synthesized experience across external task environments.

cs.CL↗

Economy of Minds: Emerging Multi-Agent Intelligence with Economic Interactions

How can a population of agents self-orchestrate and self-adapt into stronger collective intelligence without centralized control? Inspired by Friedrich Hayek's economic theory of decentralized coordination in markets, we study this question through an agent economy in which agents compete via auctions for the right to act, exchange payments, and accumulate wealth from environmental rewards. These simple local incentives induce decentralized credit assignment, driving global planning without explicit orchestration or communication protocols. The population evolves through economic selection: effective agents accumulate wealth and are mutated via exploitation, while ineffective ones go bankrupt and are replaced via exploration. Using modern Large Language Model (LLM) based agents, we show that, initialized with weak agents, the agent economy produces emergent multi-step reasoning strategies and outperforms stronger monolithic baselines across five agentic tasks, including mathematical reasoning, financial research, scientific research, accelerator design, and distributed-system optimization. Our results suggest a new path to multi-agent intelligence: rather than engineering coordination, we can design decentralized incentive structures under which it automatically emerges.

cs.CL↗

Travel Back To Move Forward: Retrospective Exploration and Evolving for Long Horizon Agents

Large language model agents increasingly operate in long-horizon environments where early mistakes can trigger cascading failures and trap agents in dead-end trajectories. Agents must therefore be able to proactively recover from such states and turn their exploratory experience into guidance for subsequent decisions. We introduce ReTRAIL, a framework that enables agents to rewind the environment to earlier states while preserving valid progress and carrying forward knowledge learned from abandoned exploration. The environment state moves backward while the agent's knowledge continues to move forward. ReTRAIL trains a shared policy with two complementary signals: State-Anchored GRPO compares alternative continuations from revisited states to improve execution, while a branch-advancement reward guides reflection through the progress of subsequent exploration. Experiments across four interactive benchmark MineSweeper, Sokoban, ALFWorld and ScienceWorld show that simply adding a rewind primitive provides limited benefit and can even degrade performance. In contrast, ReTRAIL enables agents to rewind from unproductive states and use insights from abandoned branches to guide subsequent exploration. These results demonstrate the value of coupling environment rewinding with experience reuse within an ongoing task for long-horizon task solving. The code is available at https://github.com/whi497/ReTRAIL.

cs.AI↗

Matched-Context Group Policy Optimization for LLM Agent Training

Training long-horizon language model agents requires assigning credit to intermediate decisions from sparse terminal feedback. Within a finite group of sibling rollouts, useful action comparisons depend on their context, evidence for both alternatives, and how that evidence enters learning. We propose Matched-Context Group Policy Optimization (MCGPO), a procedure for constructing weighted action preferences from already collected trajectories. MCGPO defines comparison contexts with pre-action state summaries and observed rubric progress, annotated by task rules. Two-action support selects among ordered exact and coarse matching rules. Fixed folds separate candidate decisions from the terminal outcomes used to orient their preferences, and support-dependent evidence weights scale an auxiliary pairwise objective alongside shared GraphGPO task learning. MCGPO reuses rollout data and each response's original history, preserving critic-free training. Across six environment-backbone settings with three training seeds each, MCGPO improves mean success over matched GraphGPO: by 0.47-1.46 percentage points on ALFWorld and WebShop with Qwen2.5-1.5B and 7B, and by 3.96 and 5.16 points on WebShop with Qwen3-4B and 8B. The ALFWorld gains build on baseline success above 92%, where remaining headroom is limited. Integrated success improves in three of four Qwen2.5 settings. Three-seed factorial controls support opposite-fold evidence and evidence weighting; joint state-rubric matching achieves the highest mean in all four representation-control settings.

cs.LG↗

TouchScale: 500 Hours of Human Vision and Touch for Visual-Tactile Learning

Large-scale egocentric human interaction data is becoming an important source of physical supervision for embodied learning, yet video alone leaves the contact and pressure that characterize physical interaction unrecorded. Recent visual-tactile datasets provide this missing supervision, but their synchronized tactile data remain far smaller in volume than human video. Moreover, the largest resources often merge recordings from different sensors or annotation procedures, which makes the effect of data scale difficult to isolate. We therefore introduce TouchScale, a 500-hour dataset of contact-rich human interaction recorded with a single unified wearable setup. Its approximately 2K predefined task descriptions span everyday activities and structured manipulation, and each recording temporally aligns egocentric RGB-D video with wrist RGB video and dense full-hand bimanual tactile measurements. Compared with prior tactile data, training on the full TouchScale raises zero-shot contact IoU on data from an unseen tactile sensor from 0.134 to 0.383. Pretraining a visual encoder on TouchScale also yields the highest action recognition accuracy on three benchmarks among the compared visual-tactile datasets. Used for visual-tactile mid-training of a robot policy, TouchScale improves the average real-world success rate across four contact-rich manipulation tasks from 22.5% to 57.5%. With the sensor and collection protocol held fixed, both zero-shot tactile prediction and robot success show an overall upward trend as more TouchScale data is used. These results suggest that human visual-tactile data collected at scale with consistent sensing benefits both perception and robot manipulation. We will publicly release TouchScale, including all synchronized visual-tactile recordings and reconstructed object models, to support future research on scalable visual-tactile learning.

cs.CV↗

VICO: Visual Environments Co-Evolving for Vision-Language Model Reasoning

Reinforcement learning with verifiable rewards (RLVR) has become a standard recipe for post-training vision-language models (VLMs), but it typically assumes a static training environment. As the actor improves, fixed tasks drift out of its learning frontier: many become trivial, others remain unsolvable; and the learning signal collapses. We argue that VLM post-training should evolve the visual environment alongside the actor, not just the actor itself. We propose VICO, a co-evolutionary framework in which an actor and an Environment-as-Rewriter (EnvRewriter) are trained jointly: the EnvRewriter edits verifiable image-side structures, such as scene graphs, chart tables, or protected region masks, and re-renders them to produce label-valid training samples whose difficulty is calibrated to the actor's current ability through a pass-rate-based reward. This loop continuously realigns task difficulty with actor capability without any additional human annotation. Across nine multimodal benchmarks spanning mathematical reasoning and visually grounded understanding, VICO-8B improves over its base model by up to +5.0% on out-of-domain tasks, surpasses the strongest self-evolution and text-editing co-evolution baselines by +4.3% and +8.4% respectively, and stays comparable to chart-specialized RLVR methods using 16-160 times fewer labeled samples. By shifting from human-labeled supervision to image-editing co-evolution, VICO offers a scalable path beyond static-corpus RLVR for visual reasoning.

cs.CV↗

AgentPersonaBench: Benchmarking Persona-Driven User Simulation

We introduce AgentPersonaBench (APB), a benchmark evaluating whether persona conditioning faithfully steers downstream agent behavior. While language models are increasingly deployed for persona-driven user simulation, existing benchmarks primarily evaluate conversational styling or self-reports rather than authentic behavioral fidelity. APB evaluates latent persona adherence one trait at a time, embedding each target trait within a complete synthetic profile without explicitly naming the trait or disclosing the test. Ground-truth adherence is verified strictly from observable actions across four interaction surfaces of increasing realism: survey, chat, web (interactive web environments), and app (desktop software environments). APB comprises 2,460 tasks spanning 867 traits, verified through automated audits and expert review. Our evaluation of 20 frontier model arms demonstrates that high-fidelity user simulation is already attainable: leading models achieve up to 84.7% full-pass adherence under unprompted conditions. At the same time, APB identifies clear behavioral boundaries: adherence drops across interaction modalities (only 37.9-64.3% pass all four surfaces), multi-attribute demands degrade retention, and competing model families exhibit pronounced behavioral divergence.

cs.AI↗

Energy of toroidal M2 brane in flat 11d background

The supermembrane action is non-linear and a priori non-renormalizable. Still, some quantities in this theory may be free of log UV divergences and thus defined unambiguously. To explore this possibility we compute the energy of an M2 brane wrapped on a 2-torus in flat 11d space to two loops in the inverse-tension expansion. The result is free of logarithmic divergences and the same should hold also at higher loop orders. For fermions periodic around both circles the quantum corrections cancel, consistent with the BPS nature of the wrapped M2 brane state. For fermions antiperiodic around one or both circles the energy is a non-trivial function of the radii given by infinite sums of modified Bessel functions. We also compute 3-loop correction to the energy of the bosonic membrane on $\mathbb R^2\times S^1$. In contrast to the string case, it contains, besides powers of the 1-loop $ζ(3)$ coefficient, a new term proportional to $ζ(9)$. Summing contributions of all-loop bubble graphs leads to a simple cubic equation for the membrane energy. The analogous resummation in the Nambu or GS string case reproduces the familiar exact square-root expression ${\mathcal E}=\sqrt{(2πR\,T_1)^2+m_0^2}$. We find that the bubble-graph part of the membrane energy does not vanish for any value of the radius $R_{11}$. If contributions of other non-trivial diagrams in the supermembrane case do not qualitatively change this conclusion, this would disfavour the conjectured relation between 11d theory on an antiperiodic circle and the strong-coupling limit of type 0A string theory.

hep-th↗