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arXiv · 2601.10917

Self-learned representation-guided latent diffusion model for breast cancer classification in deep ultraviolet whole surface images

Pouya Afshin·David Helminiak·Tianling Niu·Julie M. Jorns·Tina Yen·Bing Yu·Dong Hye Ye
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Abstract

Breast-Conserving Surgery (BCS) requires precise intraoperative margin assessment to preserve healthy tissue. Deep Ultraviolet Fluorescence Scanning Microscopy (DUV-FSM) offers rapid, high-resolution surface imaging for this purpose; however, the scarcity of annotated DUV data hinders the training of robust deep learning models. To address this, we propose an Self-Supervised Learning (SSL)-guided Latent Diffusion Model (LDM) to generate high-quality synthetic training patches. By guiding the LDM with embeddings from a fine-tuned DINO teacher, we inject rich semantic details of cellular structures into the synthetic data. We combine real and synthetic patches to fine-tune a Vision Transformer (ViT), utilizing patch prediction aggregation for WSI-level classification. Experiments using 5-fold cross-validation demonstrate that our method achieves 96.47 % accuracy and reduces the FID score to 45.72, significantly outperforming class-conditioned baselines.

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Pouya Afshin, David Helminiak, Tianling Niu, Julie M. Jorns, Tina Yen, Bing Yu, Dong Hye Ye. 2026-01-24. Self-learned representation-guided latent diffusion model for breast cancer classification in deep ultraviolet whole surface images. https://arxiv.org/abs/2601.10917

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